which of the following region is likely to be affected in the sickle cell allele? course hero

What are the effects of sickle cell disease on the circulatory system?

Sickle cell disease is caused by a substitution in the beta globin gene. As a result, one amino acid is different in the mutant protein. Which of the following region is likely to be affected in the sickle cell allele? A. The promoter region B. The 5' UTR region C. The coding region D. The 3'

Is there natural selection in sickle cell disease (SCD)?

Feb 05, 2019 · Ex 4 [ 4 ] The sickle-cell allele most likely originated when a mutation occurred in a normal hemoglobin allele. [ 4.1 ] Nobody knows for sure where or when the first sickle-cell allele mutation occurred . Do you think that the climate conditions in different regions of Africa may have affected where or when the mutation first occurred? Explain.

What is the genotype for sickle cell anemia?

Sep 15, 2011 · a) The HbA allele frequency increases and the HbS frequency decreases . 5. In which of the regions below is sickle cell death rate likely to be the highest? a) Region 1: malaria death rate is 0.30. b) Region 2: malaria death rate is 0.01. c) Region 3: malaria death rate is 0.15. d) Region 4: malaria death rate is 0.08.

What do alleles represent in a population?

Jan 12, 2021 · Ex 4[ 4 ] The sickle-cell allele most likely originated when a mutation occurred in a normal hemoglobin allele. [ 4.1 ] Nobody knows for sure where or when the first sickle-cell allele mutation occurred. Do you think that the climate conditions in different regions of Africa may have affected where or when the mutation first occurred? Explain.

In what region of Africa will there be the highest frequency of sickle cell carriers and why?

The disease is most common in sub-Saharan Africa, where as many as 45% of people are carriers. It has become so widespread there because being a carrier offers a survival advantage against malaria. The Middle East doesn't really have a malaria problem, and the overall sickle-cell carrier rate is low.Aug 25, 2021

Where is the sickle cell allele most frequent?

The allele for sickle-cell disease is most common in people of African ancestry. The reason for this probably has to do with the relationship between the sickle-cell trait and malaria. Malaria, a disease common in parts of Africa, affects red blood cells.

Why is the sickle cell allele common in tropical regions?

Sickle-cell disease is common in tropical and sub-tropical regions because being a carrier, carrying a single sickle-cell mutation (sickle cell trait), affords some resistance to malaria.Aug 13, 2020

Which allele is responsible for sickle-cell anemia?

Sickle cell disease is caused by a variant of the beta-globin gene called sickle hemoglobin (Hb S). Inherited autosomal recessively, either two copies of Hb S or one copy of Hb S plus another beta-globin variant (such as Hb C) are required for disease expression.

Who does sickle cell affect the most?

Who gets sickle cell anemia? In the United States, the disease occurs most often among African Americans (in about 1 of every 400 African American births) and among Hispanics of Caribbean ancestry (1 in every 1,000 to 1,400 Hispanic American children).May 31, 2019

Do you think the allele for sickle cell anemia would be common in regions where malaria did not exist explain why or why not?

There are many genes that influence just this. For example, a genetic variance causing sickle cell anemia actually protects against another disease, malaria. This explains why the gene for sickle cell anemia is found in about 7% of the population in malaria-stricken regions, but is virtually nonexistent elsewhere.Jul 12, 2018

Where is sickle cell most common and why?

Sickle cell disease (SCD) affects millions of people throughout the world and is particularly common among those whose ancestors came from sub-Saharan Africa; Spanish-speaking regions in the Western Hemisphere (South America, the Caribbean, and Central America); Saudi Arabia; India; and Mediterranean countries such as ...

How does sickle cell affect malaria?

The sickle cells have membranes, stretched by their unusual shape, that become porous and leak nutrients that the parasites need to survive and the faulty cells eventually get eliminated quite fast by the organisms, destroying the parasite along the way.Jun 19, 2019

Where is the sickle cell mutation?

Sickle cell disease occurs when a person inherits two abnormal copies of the β-globin gene (HBB) that makes haemoglobin, one from each parent. This gene occurs in chromosome 11. Several subtypes exist, depending on the exact mutation in each haemoglobin gene.

Is sickle cell anemia homozygous or heterozygous?

Genetics. Sickle cell disease comprises a group of heterogenous disorders that share the presence of the gene for HbS, either homozygous (i.e., sickle cell anemia, HbSS) or double heterozygous (i.e., the combination of HbS with another abnormal hemoglobin). Sickle cell anemia is the most common form.

Which amino acid causes sickle cell anemia?

Sickle cell anemia results from the single amino acid substitution of valine for glutamic acid in the beta-chain owing to a nucleotide defect that causes the production of abnormal beta-chains in hemoglobin S.