A short-course RT regimen of 25 Gy in 5 fractions is an acceptable treatment option for patients aged ≥65 years, mainly those with a poor performance status or contraindication to chemotherapy, which would be indicated in cases of methylated O6 methylguanine-DNA-methyltransferase promoter tumors.
Short-course radiotherapy, a standard approach throughout most of northern Europe, is generally defined as 25 Gy in 5 fractions over the course of 1 week without the concurrent administration of chemotherapy. Long-course radiotherapy is typically defined as 45 to 50.4 Gy in 25-28 fractions with the administration of concurrent 5-fluoropyrimidine-based chemotherapy and is the …
Patients allocated to the standard of care group received 28 daily fractions of 1·8 Gy up to 50·4 Gy or 25 fractions of 2·0 Gy up to 50·0 Gy (per physician discretion or hospital policy), with concomitant twice-daily oral capecitabine 825 mg/m 2 followed by total mesorectal excision and, if stipulated by hospital policy, adjuvant chemotherapy with eight cycles of CAPOX or 12 cycles …
Sep 24, 2012 · There are two broad approaches to preoperative pelvic radiation therapy for resectable rectal cancer: short-course radiation and long-course chemoradiotherapy. Although the radiation techniques are similar, the fractionation and timing of surgery differ. In general, short-course radiation delivers 25 Gy (5 Gy in five fractions) of radiation followed by surgery 1 week …
Short-course radiation therapy uses 1 week of radiation without chemotherapy (5 Gy × 5) followed by surgery the next week. In contrast, standard chemoradiation uses 45–50.4 Gy in 25–28 fractions with concurrent 5-FU chemotherapy followed by 4–8 weeks of rest before surgery.
Long-course radiotherapy is typically defined as 45 to 50.4 Gy in 25-28 fractions with the administration of concurrent 5-fluoropyrimidine-based chemotherapy and is the standard approach in other parts of Europe and the United States.
Short-course radiotherapy typically involves 25 Gy in 5 fractions given in 1 week,7 whereas long-course treatment consists of 45 Gy given in 25 fractions over 5 weeks as standard8 with concomitant chemotherapy as a radiosensitizer.
Chemoradiotherapy (CRT, CRTx, CT-RT) is the combination of chemotherapy and radiotherapy to treat cancer. Synonyms include radiochemotherapy (RCT, RCTx, RT-CT) and chemoradiation. It is a type of multimodal cancer therapy.
Total neoadjuvant therapy (TNT) is a novel approach for locally advanced rectal cancer (LARC), which attempts to deliver both systemic chemotherapy and neoadjuvant chemoradiotherapy prior to surgery.May 13, 2021
FOLFOX is an abbreviation for a type of chemotherapy regimen typically used to treat colorectal cancer. Its name comes from the three types of chemotherapy drugs used during treatment: FOLinic acid. Fluorouracil. OXaliplatin.Jun 16, 2021
Chemoradiation is when chemotherapy and radiotherapy are given at the same time. It is sometimes called chemoradiotherapy. Chemoradiation may be given for rectal cancer: before surgery, to help shrink the cancer and reduce the risk of cancer coming back in or around the rectum.
When it comes to side effects, radiation therapy is a little different than chemotherapy in that it only causes side effects in the area being treated (with the exception of fatigue), and generally has risk for both early and late side effects.Jan 29, 2018
Cisplatin, a chemotherapy drug, is best known for curing testicular cancer. It is also used in the treatment of a wide range of other cancers, including lung, bladder, cervical, and ovarian cancers.May 30, 2014