how long does it take for legionnaires disease to run its course

by Freeda Koss 6 min read

How long does it take to develop symptoms of Legionnaires’ disease?

This course has great information; I now feel like I have a better understanding of the disease and steps to reduce risk.”-TRAIN user. How Long Does It Take? Pilot testers took an average of a half hour to complete each module and an average of 3 hours to complete the training as a whole. Users do not have to complete the training all at once.

How does Legionnaires’ disease spread?

 · Legionnaires’ disease will usually start causing symptoms within 2 to 14 days after exposure to the bacteria. This period is called the incubation period.

How is Legionnaires’ disease treated?

 · The incubation period for Legionnaires’ disease, which is the time between exposure to the infectious agent and the onset of symptoms, is two to 10 days. Longer incubation periods have been recorded in a minority of cases, for example in immunocompromised patients.

How serious is Legionnaires’ disease?

Most healthy people exposed to Legionella do not get sick. People at increased risk of getting sick are: People 50 years or older; Current or former smokers; People with a chronic lung disease (like chronic obstructive pulmonary disease or emphysema)

How deadly is Legionnaires disease?

In general, Legionnaires’ disease is deadly for about 10% of people who get it. 2 It is deadly for about 25% of people who get it from a healthcare facility. 3. CDC investigations show almost all (9 in 10) Legionnaires’ disease outbreaks were caused by problems preventable with more effective water management. 4.

What is Legionella?

Legionella – bacteria that can cause Legionnaires’ disease or Pontiac fever, collectively known as legionellosis. CDC scientists identified and named the bacterium after an outbreak in 1976 when many people who went to a Philadelphia convention of the American Legion got sick with pneumonia.

When was Legionella named?

CDC scientists identified and named the bacterium after an outbreak in 1976 when many people who went to a Philadelphia convention of the American Legion got sick with pneumonia. Water management program – program to reduce the risk of Legionella growth and spread.

How long does it take to complete pilot testing?

Pilot testers took an average of a half hour to complete each module and an average of 3 hours to complete the training as a whole. Users do not have to complete the training all at once. They can save their progress and come back later to complete a module.

When do Legionnaires disease outbreaks occur?

When outbreaks do occur, they are usually in the summer and early autumn, though cases may occur at any time of year.

How is Legionnaires disease transmitted?

Transmission. Legionnaires' disease is usually spread by the breathing in of aerosolized water or soil contaminated with the Legionella bacteria. Experts have stated that Legionnaires' disease is not transmitted from person to person. In 2014, one case of possible spread from someone sick to the caregiver occurred.

How to prevent Legionnaires disease?

Although the risk of Legionnaires' disease being spread by large-scale water systems cannot be eliminated, it can be greatly reduced by writing and enforcing a highly detailed, systematic water safety plan appropriate for the specific facility involved (office building, hospital, hotel, spa, cruise ship, etc.) Some of the elements that such a plan may include are: 1 Keep water temperature either above or below the 20–50 °C (68–122 °F) range in which the Legionella bacterium thrives. 2 Prevent stagnation, for example, by removing from a network of pipes any sections that have no outlet (dead ends). Where stagnation is unavoidable, as when a wing of a hotel is closed for the off-season, systems must be thoroughly disinfected just prior to resuming normal operation. 3 Prevent the buildup of biofilm, for example, by not using (or by replacing) construction materials that encourage its development, and by reducing the quantity of nutrients for bacterial growth that enter the system. 4 Periodically disinfect the system, by high heat or a chemical biocide, and use chlorination where appropriate. Treatment of water with copper-silver ionization or ultraviolet light may also be effective. 5 System design (or renovation) can reduce the production of aerosols and reduce human exposure to them, by directing them well away from building air intakes.

What is the fatality rate of Legionnaires disease?

The fatality rate is around 10% for healthy persons and 25% for those with underlying conditions. The number of cases that occur globally is not known. Legionnaires' disease is the cause of an estimated 2–9% of pneumonia cases that are acquired outside of a hospital.

How many people develop Legionnaires disease?

For the general population, among those exposed, between 0.1 and 5.0% develop the disease, while among those in hospital, between 0.4 and 14% develop the disease. Those with Legionnaires' disease usually have fever, chills, and a cough, which may be dry or may produce sputum.

Does Legionnaires disease cause diarrhea?

Up to half of those with Legionnaires' disease have gastrointestinal symptoms, and almost half have neurological symptoms, including confusion and impaired cognition.

What are the symptoms of Legionella pneumonia?

Signs and symptoms include cough, shortness of breath, high fever, muscle pains, and headaches. Nausea, vomiting, and diarrhea may also occur. This often begins 2–10 days after exposure.

How long does it take for Legionnaires to show symptoms?

Legionnaires’ disease will usually start causing symptoms within 2 to 14 days after exposure to the bacteria. This period is called the incubation period. The symptoms of Legionnaires’ disease are similar to those of other types of pneumonia. The most common symptoms include:

What is Legionnaires disease?

What is Legionnaires’ disease? Legionnaires’ disease is a severe type of pneumonia, or lung infection. Bacteria called Legionella cause this infection. The bacteria were discovered after an outbreak at a Philadelphia convention of the American Legion in 1976.

What is Legionella bacteria?

Bacteria called Legionella cause this infection. The bacteria were discovered after an outbreak at a Philadelphia convention of the American Legion in 1976. Those who were affected developed a form of pneumonia that eventually became known as Legionnaires’ disease. Legionella bacteria thrive in warm water.

When was Legionella discovered?

The bacteria were discovered after an outbreak at a Philadelphia convention of the American Legion in 1976. Those who were affected developed a form of pneumonia that eventually became known as Legionnaires’ disease. Legionella bacteria thrive in warm water.

How do you get Legionella?

People become infected with Legionella by breathing in contaminated droplets of water in the air. Outbreaks have been linked to water systems in hospital buildings and to whirlpool spas in hotels and cruise ships. are hospitalized in the United States each year with Legionnaires’ disease.

How many people are hospitalized with Legionnaires?

Approximately 5,000 people. Trusted Source. are hospitalized in the United States each year with Legionnaires’ disease. However, the number of infections is probably higher, because many infections aren’t diagnosed or reported. Some cases are so mild that affected individuals never seek treatment.

Why is the number of Legionnaires disease cases higher?

However, the number of infections is probably higher, because many infections aren’t diagnosed or reported. Some cases are so mild that affected individuals never seek treatment.

How long do you have to stay in a hospital for Legionella?

Patients with an overnight stay in a healthcare facility within 14 days before symptom onset. Patients with an epidemiologic link to a setting with a confirmed source of Legionella or that has been associated with at least one laboratory-confirmed case of Legionnaires’ disease.

What is the most common test for Legionnaires disease?

The most commonly used laboratory test for diagnosis of Legionnaires’ disease is the urinary antigen test (UAT), which detects a molecule of the Legionella bacterium in urine. If the patient has pneumonia and the test is positive, then you should consider the patient to have Legionnaires’ disease. The test can remain positive for a few weeks after infection, even with antibiotic treatment. The UAT detects the most common cause of Legionnaires’ disease, L. pneumophila serogroup 1. However, all species and serogroups of Legionella are potentially pathogenic, so a patient with a negative urinary antigen result could have Legionnaires’ disease caused by other Legionella species or serogroups, which is why using culture and UAT in combination is recommended.

What is the best test for Legionella?

The preferred diagnostic tests for Legionnaires’ disease are culture of lower respiratory secretions (e.g., sputum, bronchoalveolar lavage) on selective media and the Legionella urinary antigen test. Serological assays can be nonspecific and are not recommended in most situations. Best practice is to obtain both sputum for culture and urine for the urinary antigen test concurrently. Sputum should ideally be obtained prior to antibiotic administration, but antibiotic treatment should not be delayed to facilitate this process. The urinary antigen test can detect Legionella infections in some cases for days to weeks after treatment.

Can a culturing specimen detect Legionella?

Unlike the urinary antigen test, culturing specimens from patients can detect all species and serogroups of Legionella. Isolating Legionella from clinical specimens helps investigators identify where exposure occurred and prevent additional cases.

Can a negative urinary antigen cause Legionella?

However, all species and serogroups of Legionella are potentially pathogenic, so a patient with a negative urinary antigen result could have Legionnaires’ disease caused by other Legionella species or serogroups, which is why using culture and UAT in combination is recommended.

Why is it important to report Legionella?

Timely identification and reporting of legionellosis cases are also important because this allows public health officials to act quickly.

How long does a UAT test stay positive?

The test can remain positive for a few weeks after infection, even with antibiotic treatment. The UAT detects the most common cause of Legionnaires’ disease, L. pneumophila serogroup 1.

How long does it take for Legionnaires to incubate?

The incubation period for Legionnaires’ disease, which is the time between exposure to the infectious agent and the onset of symptoms, is two to 10 days. Longer incubation periods have been recorded in a minority of cases, for example in immunocompromised patients.

What age does Legionnaires disease affect?

Legionnaires’ disease often affects individuals over the age of 50, people who are heavy smokers and immunocompromised individuals. Legionnaires’ disease presents similarly to other bacterial pneumonias, such as pneumococcal pneumonia, with signs and symptoms like high fever, cough, chills, difficulty breathing (dyspnea), headache, chest pain, ...

When was Legionnaires disease first recognized?

Introduction. Legionnaires’ disease was initially recognized in early 1977, when an outbreak of a form of pneumonia affected members attending an American Legion Convention at a hotel in Philadelphia in 1976. The bacterium responsible for the disease was identified and named Legionella pneumophila by the CDC.

How many cases of Legionnaires disease in the USA?

The incidence of Legionnaires’ disease in the USA was estimated to be 10,000 cases in 2018. There is seasonal variation as most patients are diagnosed in the summer and early autumn. Studies show that most cases were community-acquired pneumonia (CAP) while about a quarter of the cases were travelled-related and less than 10% were health-care-related. However, it is hard to get an accurate estimate of the incidence of this disease since it is underdiagnosed, underreported and it has been shown that some people will develop only mild illness or show no symptoms at all.

Why do hospitalized patients have Legionnaires disease?

Hospitalized patients can be at an increased risk of contracting Legionnaires’ disease in certain situations such as after an organ transplant, after receiving general anesthesia because of the increased risk of aspiration or use of immunosuppressant drugs.

What is the best treatment for Legionnaires disease?

Legionnaires’ disease is treated effectively by many classes of antibiotics: macrolides, tetracyclines, ketolides and quinolones. The first line of treatment is a course of azithromycin, doxycycline or levofloxacin on an outpatient basis.

What causes Legionella pneumonia?

Legionnaires’ disease, caused by the aerobic gram-negative coccobacillus Legionella, mostly L. pneumophila , is an important cause of community-acquired pneumonia (CAP), accounting for approximatively 10% of cases. The exact incidence of Legionnaires’ disease is unknown due to different awareness levels in different countries, diagnostic methods and reporting, but the US Centers for Disease control (CDC) reported nearly 10,000 cases in the USA in 2018. Infection with Legionella occurs through the inhalation of an aerosol containing bacteria generated by water droplets, usually coming from a contaminated water system. It does not spread from person-to-person. Legionnaires’ disease often affects individuals over the age of 50, people who are heavy smokers and immunocompromised individuals.

Can you spread Legionnaires disease to other people?

In general, people do not spread Legionnaires’ disease and Pontiac fever to other people. However, this may be possible under rare circumstances. 1. You develop symptoms, such as fever, cough, chills, or muscle aches. Your local health department can determine whether to investigate.

How does Legionella spread?

How It Spreads. After Legionella grows and multiplies in a building water system, water containing Legionella can spread in droplets small enough for people to breathe in. People can get Legionnaires’ disease or Pontiac fever when they breathe in small droplets of water in the air that contain the bacteria. Less commonly, people can get sick by ...

Can Legionella be spread in water?

After Legionella grows and multiplies in a building water system, water containing Legionella can spread in droplets small enough for people to breathe in. People can get Legionnaires’ disease or Pontiac fever when they breathe in small droplets of water in the air that contain the bacteria.

Can you spread Legionella to other people?

In general, people do not spread Legionnaires’ disease and Pontiac fever to other people. However, this may be possible under rare circumstances. 1. Talk to your doctor or local health department if. You believe you were exposed to Legionella. AND. You develop symptoms, such as fever, cough, chills, or muscle aches.

Where can Legionella be found?

Legionella bacteria are found naturally in freshwater environments, like lakes and streams. The bacteria can become a health concern when they grow and spread in human-made building water systems like

How does Legionella spread?

To do this, Legionella first has to grow (increase in numbers). Then it has to spread through small water droplets (aerosolization) that people can breathe in. You can take steps to reduce the risk for Legionella in your building.

Can you get Legionnaires disease from drinking water?

People at Risk for Legionnaires’ Disease. People can get Legionnaires’ disease if they breathe in water droplets containing Legionella or if contaminated water goes into the lungs while drinking.

Can Legionella be spread through water?

However, Legionella can pose a health risk when it gets into building water systems. To do this, Legionella first has to grow (increase in numbers). Then it has to spread through small water droplets (aerosolization) that people can breathe in. You can take steps to reduce the risk for Legionella in your building.

Where does Legionella occur?

Legionella, the bacterium that causes Legionnaires’ disease, occurs naturally in freshwater environments, like lakes and streams. Generally the low amounts of these bacteria in freshwater do not lead to disease. However, Legionella can pose a health risk when it gets into building water systems. To do this, Legionella first has to grow (increase in ...

Can Legionella grow in water?

When there is a reduction in disinfectant levels in your building water systems, Legionella can grow. In some buildings, processes such as heating, storing, and filtering can reduce the amount of available disinfectant, allowing Legionella to grow if steps are not taken to stop it.

Does heating water help Legionella?

In some buildings, processes such as heating, storing, and filtering can reduce the amount of available disinfectant, allowing Legionella to grow if steps are not taken to stop it. Your building water supply may need long-term supplemental disinfectants added to the water to boost the level of disinfectant and help limit Legionella growth.

What temperature does Legionella grow?

Legionella grows best within a certain temperature range (77°F-113°F). To keep water outside the range for Legionella growth, it is important to keep cold water cold and keep hot water hot. A note about cold water: In warm climates, water in pipes that carry cold water may reach a temperature that allows Legionella to grow.

How do you treat Legionnaires disease?

Legionnaires’ disease is treated with antibiotics (drugs that kill bacteria in the body). Most people who get sick need care in a hospital but make a full recovery. However, about 1 out of 10 people who get Legionnaires’ disease will die from the infection.

Can Legionella grow in water?

In nature, Legionella live in fresh water and rarely cause illness. In man-made settings, Legionella can grow if water is not properly maintained. These man-made water sources become a health problem when small droplets of water that contain the bacteria get into the air and people breathe them in. In rare cases, someone breathes in Legionella while they are drinking water and it “goes down the wrong pipe” into the lungs. In general, people do not spread Legionnaires’ disease to other people.

Can you get Legionella if you are 50?

Most healthy people do not get Legionnaires’ disease after being exposed to Legionella. Being 50 years or older or having certain risk factors can increase your chances of getting sick. These risk factors include:

When is Legionnaires disease most commonly diagnosed?

This disease is most commonly diagnosed in the summer months. Here are four key things you should know about Legionnaires' disease. People who are 50 years or older are more likely to get sick if they are exposed to the bacteria that cause Legionnaires' disease.

What is Legionnaires disease?

A mysterious illness made headlines in Philadelphia this month in 1976. The illness caused a serious type of pneumonia — 182 people got sick and 29 people died. Eventually, this illness would become known as Legionnaires' disease.

How many people died from Legionnaires disease in 1976?

A mysterious illness made headlines in Philadelphia this month in 1976. The illness caused a serious type of pneumonia — 182 people got sick and 29 people died. Eventually, this illness would become known as Legionnaires' disease. Forty years after that first outbreak, Legionnaires' disease is a growing health concern.

Can you get Legionnaires disease after being exposed to a syringe?

Fortunately, most healthy people do not get Legionnaires' disease after being exposed. Like other types of pneumonia, signs and symptoms of Legionnaires' disease can include cough, muscle aches, fever, shortness of breath and headache. Most people with Legionnaires' disease need care in a hospital, but will fully recover with treatment.

How does Legionella get into the lungs?

To get sick, people have to breathe the bacteria into their lungs. Legionella is usually spread through water droplets in the air (mist), but in rare cases people can get sick after contaminated drinking water is swallowed “down the wrong pipe” into the lungs.

Can you get Legionnaires disease from contaminated water?

Legionnaires' disease is serious but can be treated. Legionnaires' disease is caused by breathing in contaminated water. See a doctor right away if you develop pneumonia symptoms.

Overview

Medically reviewed by
Dr. Govind Desai
A lung infection caused by bacteria Legionella. It causes fever, headache, cough and shortness of breath.
Condition Highlight
Urgent medical attention is usually recommended in severe cases by healthcare providers
Condition Highlight
Certain types can be dangerous or life threatening
How common is condition?
Very rare (Fewer than 20,000 cases per year in US)
Is condition treatable?
Treatable by a medical professional
Does diagnosis require lab test or imaging?
Requires lab test or imaging
Time taken for recovery
Can last several days or weeks
How is condition transmitted?
Transmitted through airborne exposure
Condition Highlight
Common for ages 50 and older
Condition Image

Signs and symptoms

Cause

Mechanism

Diagnosis

Prevention

The length of time between exposure to the bacteria and the appearance of symptoms (incubation period) is generally 2–10 days, but can more rarely extend to as long as 20 days. For the general population, among those exposed, between 0.1 and 5.0% develop the disease, while among those in hospital, between 0.4 and 14% develop the disease.
Those with Legionnaires' disease usually have fever, chills, and a cough, which may be dry or ma…

Treatment

Over 90% of cases of Legionnaires' disease are caused by Legionella pneumophila. Other types include L. longbeachae, L. feeleii, L. micdadei, and L. anisa.
Legionnaires' disease is usually spread by the breathing in of aerosolizedwater or soil contaminated with the Legionella bacteria. Experts have stated that Leg…

Prognosis

Legionella spp. enter the lungs either by aspiration of contaminated water or inhalation of aerosolized contaminated water or soil. In the lung, the bacteria are consumed by macrophages, a type of white blood cell, inside of which the Legionella bacteria multiply, causing the death of the macrophage. Once the macrophage dies, the bacteria are released from the dead cell to infect other macrophages. Virulent strains of Legionella kill macrophages by blocking the fusion of pha…

Sensitivity and Specificity of Diagnostic Tests

People of any age may suffer from Legionnaires' disease, but the illness most often affects middle-aged and older people, particularly those who smoke cigarettes or have chronic lung disease. Immunocompromised people are also at higher risk. Pontiac fever most commonly occurs in those who are otherwise healthy.

Advantages and Disadvantages For Each Diagnostic Test

Although the risk of Legionnaires' disease being spread by large-scale water systems cannot be eliminated, it can be greatly reduced by writing and enforcing a highly detailed, systematic water safety plan appropriate for the specific facility involved (office building, hospital, hotel, spa, cruise ship, etc.) Some of the elements that such a plan may include are:
• Keep water temperature either above or below the 20–50 °C (68–122 °F) range in which the Le…

Treatment

Effective antibiotics include most macrolides, tetracyclines, ketolides, and quinolones. Legionella spp. multiply within the cell, so any effective treatment must have excellent intracellular penetration. Current treatments of choice are the respiratory tract quinolones (levofloxacin, moxifloxacin, gemifloxacin) or newer macrolides (azithromycin, clarithromycin, roxithromycin). The antibiotics used most frequently have been levofloxacin, doxycycline, and azithromycin.

Prevention

The fatality rate of Legionnaires' disease has ranged from 5–30% during various outbreaks and approaches 50% for nosocomial infections, especially when treatment with antibiotics is delayed. Hospital-acquired Legionella pneumonia has a fatality rate of 28%, and the principal source of infection in such cases is the drinking-water distribution system.

Reporting

  • Sensitivity varies depending on the quality and timing of clinical specimen collection, as well as technical skill of the laboratory worker performing the test. The table below provides general ranges for the sensitivity and specificity of each diagnostic test. 1 Cross reactions with other species and serogroups have been documented. 2Avni T, Biebe...
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