This is because it is know that boys with familial male precocious puberty go into true puberty too early (despite treatment with spironolactone and testolactone), and when that happens, the spironolactone and testolactone are no longer as effective.
Treatment of Boys With Precocious Puberty. The study therefore uses spironolactone to prevent the action of the male hormones (androgen) and testolactone to block the production of female hormones (estrogen). Deslorelin, an LHRH analog which works by turning off true (central) puberty, is added to the drug regimen once true puberty begins.
It occurs because their bones mature and stop growing too quickly. This is one condition that can be positively affected by puberty blockers. (Because of social expectations about gender, short stature is considered to be more of an issue for cisgender boys.) Evidence for other problems associated with precocious puberty is more mixed.
Learn more. Anita Sadaty, MD, is a board-certified obstetrician-gynecologist at North Shore University Hospital and founder of Redefining Health Medical. Precocious puberty is when a child starts to show signs of puberty earlier than is considered to be normal.