ctHb, the total hemoglobin concentration is typically defined as the sum of oxygenated hemoglobin, deoxygenated hemoglobin, carboxyhemoglobin and methemoglobin.
fourThe hemoglobin molecule has four binding sites for oxygen molecules: the iron atoms in the four heme groups. Thus, each Hb tetramer can bind four oxygen molecules. From the molecular weight of Hb, one can calculate that 1 g of Hb can combine with 1.39 ml of oxygen.
A single RBC contains about 300 million haemoglobin molecules, so a RBC can transport 1.2 billion molecules of oxygen! Almost all of the oxygen in the blood is transported by haemoglobin.
Iron is an essential element for blood production. About 70 percent of your body's iron is found in the red blood cells of your blood called hemoglobin and in muscle cells called myoglobin.
Four different hemoglobin species are commonly recognized: oxyhemoglobin (oxy-Hb), deoxyhemoglobin (deoxy-Hb), methemoglobin (met-Hb), and hemichromes, whose structures appear below. Following this evolutionary transition methemoglobin and hemichromes are enzymatically cleaved into multiple small fragments.
four oxygen moleculesHemoglobin. Hemoglobin, or Hb, is a protein molecule found in red blood cells (erythrocytes) made of four subunits: two alpha subunits and two beta subunits. Each subunit surrounds a central heme group that contains iron and binds one oxygen molecule, allowing each hemoglobin molecule to bind four oxygen molecules.
Women usually have a lower RBC count than men, and the level of red blood cells tends to decrease with age. A normal RBC count would be: men – 4.7 to 6.1 million cells per microlitre (cells/mcL) women – 4.2 to 5.4 million cells/mcL.
(b) A single erythrocyte can contain 300 million hemoglobin molecules, and thus more than 1 billion oxygen molecules. Each iron ion in the heme can bind to one oxygen molecule; therefore, each hemoglobin molecule can transport four oxygen molecules.
Men: 4.7 to 6.1 million red blood cells per microliter of blood. Women: 4.2 to 5.4 million red blood cells per microliter of blood. Children: 4.0 to 5.5 million red blood cells per microliter of blood.
Normal hemoglobin A1c levels range between 4% to 5.9%. As this number reaches 6% or greater, it signifies poorer diabetes control. A hemoglobin A1c of 6% roughly correlates with an average blood sugar level of 135 mg/dL (milligrams per deciliters) over the previous 3 months.
Normal levels are generally between 35.5 and 44.9 percent for adult women and 38.3 to 48.6 percent for adult men. These values may change depending on your age.
Males of average height have about 4 grams of iron in their body, females about 3.5 grams; children will usually have 3 grams or less. These 3-4 grams are distributed throughout the body in hemoglobin, tissues, muscles, bone marrow, blood proteins, enzymes, ferritin, hemosiderin, and transport in plasma.