why does hcg fall during the course of pregnancy

by Rafaela Rosenbaum 10 min read

Around the third or fourth month of pregnancy, hCG levels start to drop on their own. This is because your fetus has a fully formed placenta, which brings oxygen and nutrients to the baby through the umbilical cord.

In the event of a miscarriage, hCG levels typically decrease from previous measurements. For example, a baseline level of 120 mIU/mL that's dropped to 80 mIU/mL two days later can indicate the embryo is no longer developing and the body isn't producing more hormones to support its growth.Feb 26, 2019

Full Answer

What causes hCG levels to rise and fall during pregnancy?

Carrying multiples (twins, triplets, etc.) can affect the rate of hCG rise, as well as how far along you are. Ectopic pregnancy and miscarriage can result in lower hCG levels. A molar pregnancy can result in higher levels. Doctors will use a variety of tests to confirm a miscarriage.

What happens to hCG levels when the gestational sac develops?

When the gestational sac develops, hCG hormone can be released, but the level does not rise since the egg doesn’t develop. This occurs very early in pregnancy. Most women won’t even know that it’s...

What does it mean if my hCG level falls?

Women whose hCG level falls over a period of two to three days in the first trimester in two quantitative hCG blood tests are often advised that this means an impending miscarriage. This is especially true for women with other miscarriage symptoms, such as vaginal bleeding during pregnancy. Decreasing hCG...

What is HCG in pregnancy?

HCG is a hormone made by the placenta. Levels of hCG surge in the first trimester of pregnancy, and they’re detectable in your urine within a day or two of implantation.

Why does hCG drop later in pregnancy?

A slow rate of rise or a drop in HCG levels during the first 8 to 10 weeks of pregnancy represents death of trophoblastic tissue and can indicate ectopic or nonviable intrauterine pregnancy. Serial quantitative HCG values are, therefore, helpful in management of threatened early pregnancies.

Do hCG levels drop during pregnancy?

Share on Pinterest Levels of hCG tend to decrease in the later stages of pregnancy. Levels of hCG typically increase in the first trimester of a healthy pregnancy. Levels of hCG usually increase during the first trimester , peak by weeks 8 to 11, and then decline to a steady level in the later stages of the pregnancy.

Does hCG start dropping before miscarriage?

In general, however, if the hCG levels are dropping in the first trimester, this probably is a sign of impending miscarriage. On the other hand, slow-rising hCG levels that do not double every two or three days in early pregnancy may be a sign of problems, but can also occur in a normal pregnancy.

Can stress cause low hCG levels?

In conclusion, stress-related hormones affect placental HCG secretion in vitro. The involvement of these factors in impairing early pregnancy development is suggested.

When do hCG levels start to drop?

In early pregnancy, hCG levels typically double about every two to three days. Levels generally peak at around 8 to 14 weeks after conception. After that they decline somewhat, and usually plateau during the second and third trimester.

How long after hCG drop did you miscarry?

A 2013 medical study that tested 443 women who had miscarriages found that hCG levels declined faster than previously thought. The researchers reported there was a 35 to 50 percent reduction in hCG levels 2 days after, and a 66 to 87 percent reduction 7 days after the pregnancy resolved.

How quickly does hCG drop in miscarriage?

It typically takes from one to nine weeks for hCG levels to return to zero following a miscarriage (or delivery). Once levels zero out, this indicates that the body has readjusted to its pre-pregnancy state—and is likely primed for conception to occur again.

Can Vanishing Twin cause hCG drop?

Vanishing twin pregnancies comprised 22.0% of twin pregnancies and demonstrated significantly lower mean 2-day ß-hCG rise than singletons and twins (126.8% compared with 149.0% and 145.1% respectively, P<0.001).

What does it mean if you don't have hCG?

If you don’t have any hCG present in your blood, this doesn’t necessarily mean you aren’t pregnant. You may be too early in your pregnancy for your hCG levels to increase. HCG levels higher than 5 million international units per milliliter (mIU/mL) typically indicate pregnancy.

Why do doctors test HCG levels?

It supports fetal growth. Doctors test hCG levels in the urine and blood to confirm pregnancy. They also use hCG blood tests to help determine if a person could be experiencing an ectopic pregnancy or miscarriage. Pregnancy, ectopic pregnancy, and miscarriage will never be diagnosed based on one hCG level alone, ...

How often does hCG double during pregnancy?

In the first four weeks of a viable pregnancy, hCG levels will typically double about every two to three days. After six weeks, the levels will double about every 96 hours.

How to tell if a miscarriage is a miscarriage?

Doctors will use a variety of tests to confirm a miscarriage. These include: 1 performing blood tests, including hCG and progesterone 2 considering symptoms, such as pelvic cramping or vaginal bleeding 3 performing a vaginal ultrasound and pelvic exam 4 conducting fetal heart scanning (if your dates indicate a fetal heartbeat should be detectable)

What happens if you lose your pregnancy?

A miscarriage that results in retained tissue increases infection and bleeding risk. For these reasons, if you’re experiencing a pregnancy loss, your doctor may recommend taking medications or having certain surgical treatments to minimize complications. Pregnancy loss can also take an emotional toll.

What to do if your HCG is dropping?

This could include progesterone blood tests and a transvaginal ultrasound to check your uterus for a gestational sac. Other symptoms, such as bleeding or cramping, will also be taken into account. In the event of a miscarriage, hCG levels typically ...

What to do if you suspect a miscarriage?

If you suspect you may be having a miscarriage, talk to your doctor. Your doctor can order tests, including the hCG blood test, to provide you with further information. If you do have a miscarriage, know that it doesn’t mean you won’t go on to have a successful pregnancy. In fact, most people do.

How often does hCG increase after a miscarriage?

Levels After Miscarriage. In the first trimester of a normal pregnancy, levels of human chorionic gonadotropin, a pregnancy hormone commonly known as hCG, increase over time. Usually, hCG levels double every two to three days in early pregnancy. 1 .

Why do doctors test HCG after a miscarriage?

It is typical for physicians to continue to test hCG levels after a miscarriage, because levels that don’t drop may require medical follow-up. In some cases, elevated hCG levels following a miscarriage can indicate a molar pregnancy, which needs to be treated. 6 .

What to do if your HCG drops?

Your doctor may: Prescribe medicines that can speed the process of miscarriage. Recommend a surgical procedure such as a D&C. Suggest that you "watch and wait," allowing the miscarriage to proceed.

How long does it take for hCG to be detected in urine?

It is the same hormone that home pregnancy tests can detect in urine about 12 to 14 days after conception.

What is the normal hCG level?

Levels of hCG can vary dramatically between women and from one pregnancy to the next in the same woman. Generally, an hCG level of less than 5 mIU/mL means a woman is not pregnant while anything 25 mIU/mL or higher indicates pregnancy. 3 .

How long does it take for hCG to double?

2 . Further into a pregnancy, when hCG levels are higher, it can take up to 96 hours for them to double.

How soon after conception can you test for HCG?

Blood tests are more sensitive and can detect the hormone as early as 11 days after conception. In most healthy pregnancies, hCG levels, measured in milli-international units per milliliter (mIU/mL), will double about every 72 hours, which is why physicians will order two consecutive tests taken two to three days apart.

Why is my HCG level lower than expected?

Your hCG levels may be lower than expected because your pregnancy isn't as far along as your provider thought. Miscarriage. If your hCG levels don't go up during early pregnancy or if they start to decline, ...

What happens if your HCG levels don't go up?

Miscarriage. If your hCG levels don't go up during early pregnancy or if they start to decline, this could signal you've had or are about to have a miscarriage. If this is the case, you may experience other signs of miscarriage, such as bleeding and abdominal pain. Blighted ovum.

What hormone is produced during pregnancy?

HCG is a hormone produced during pregnancy. The letters stand for human Chorionic Gonadotropin. After an egg is fertilized and implants in the uterus, the cells that will eventually form the placenta start making hCG. HCG is often the first indicator of pregnancy.

How long does it take for HCG to show up in urine?

However, most women first discover they're pregnant using a store-bought home pregnancy test, which measures hCG levels in the urine. HCG is detectable in urine at around 12 to 14 days after conception.

How often does HCG increase during pregnancy?

It can be detected early in pregnancy through a blood test or a home pregnancy test. During early pregnancy, hCG levels typically double every two to three days.

How many days apart should I take my HCG test?

These blood tests, taken two to three days apart, can tell your provider whether your hCG levels are trending in the right direction.

What does low HCG mean?

Low hCG levels in pregnancy can be a sign of the following: Your due date was miscalculated. Providers typically calculate your baby's gestational age and your due date based on the date of your last period.

Why do hCG levels vary?

Standard hCG levels. Standard hCG levels vary quite massively from woman to woman. This is because hCG levels really depend on what is normal for you, how your body responds to pregnancy, as well as how many embryos you are carrying. The way a woman’s body reacts to pregnancy is entirely unique.

Why is hCG important for pregnancy?

The purpose of the hormone is to tell your body to continue to produce progesterone, which prevents menstruation from occurring. This protects the endometrial uterine lining and your pregnancy. A pregnancy test can detect hCG in your urine if your levels are high enough. This is how the test identifies that you are pregnant.

What is an ectopic pregnancy?

Ectopic pregnancy. An ectopic pregnancy is when the fertilized egg remains in the fallopian tube and continues to develop. It’s a dangerous and life-threatening condition, as it may cause the fallopian tube to rupture and bleed excessively. Low hCG levels can help to indicate an ectopic pregnancy. At first the symptoms of an ectopic pregnancy can ...

Why is my HCG low?

When low hCG levels are detected, it’s often because a pregnancy that was thought to be between 6 and 12 weeks is actually not that far along. An ultrasound and further hCG tests can be used to calculate the gestational age correctly. This is usually the first step when low hCG levels are detected.

What does low HCG mean?

A miscarriage is a pregnancy loss that occurs before 20 weeks of gestation. Sometimes low hCG levels can indicate that you have had or will have a miscarriage. If the pregnancy fails to develop a placenta, then the levels may be normal initially but fail to rise. Common signs that you are experiencing a miscarriage are:

What happens when an egg is fertilized and attaches to the wall of your womb?

Blighted ovum. This is when an egg is fertilized and attaches to the wall of your womb, but does not continue to develop. When the gestational sac develops, hCG hormone can be released, but the level does not rise since the egg doesn’t develop. This occurs very early in pregnancy.

How often does hCG increase during pregnancy?

In early pregnancy, hCG levels usually double every two to three days. Interestingly, when the measurements start off high they don’t expand at the same rate. If they start off more slowly, the increase ends up happening much quicker.

Why is hCG low in pregnancy?

This may occur because very early on in your pregnancy, the levels of hCG may be so low that an at-home pregnancy test might not be sensitive enough to pick up on the hormone. A blood test is the most accurate way to detect hCG levels, because more of the pregnancy hormone is present in the blood than in the urine.

What does it mean when your HCG is high?

A higher-than-normal level of hCG may indicate that you’re having twins or triplets. If you’ve just found out you’re pregnant, you can get an estimate of your due date with our Due Date Calculator above using either the date of conception or the date of the first day of your last menstrual period.

What hormones are produced during pregnancy?

Human chorionic gonadotropin is known as a pregnancy hormone as it's produced in large amounts when you are pregnant. Early on in your pregnancy, the embryo starts to make more hCG as well as other hormones like estrogen and progesterone. These hormones help build up the lining of the uterus and send signals to the ovaries to stop releasing eggs, ...

What does it mean if your HCG is positive?

If your home pregnancy test is positive, your healthcare provider may offer a blood test to check your hCG levels. The results can help your provider confirm your pregnancy and determine how far along you are. A higher-than-normal level of hCG may indicate that you’re having twins or triplets.

Why is hCG important?

The hCG hormone plays an important role in your pregnancy, and the changing levels of this hormone in your body are just one of many transformations your body goes through as your baby develops. Although hormonal changes can make you feel a little off from time to time during your pregnancy, try to take these as reassurance ...

How soon after your period can you test for pregnancy?

You might try taking a pregnancy test about three to four weeks after the first day of your period, as this is when the levels of hCG in your urine will have increased enough to be detected. You might like to wait until around the time you miss your first period, which may be when you first start to suspect that you may be pregnant anyway.

How low is hCG?

It's worth knowing that non-pregnant women and healthy men also have low levels of hCG. Normally, hCG levels would be less than 5 mIU/mL and less than 2 mIU/mL respectively for these groups.

What is the role of hCG in pregnancy?

The Role of hCG in Pregnancy. The abbreviation hCG is short for human chorionic gonadotropin. It is a hormone produced by a developing embryo during pregnancy. The hormone has an important role in both the detection and the maintenance of pregnancy. Pregnant women have very high hCG levels, but nonpregnant women and men do not have ...

How does hCG help with pregnancy?

By maintaining the corpus luteum that surrounds the egg, hCG also maintains the lining of the uterus, which is necessary to sustain a pregnancy if an egg is fertilized. When the corpus luteum surrounding an unfertilized egg dies, falling hormone levels cause the uterine lining to slough, which results in a menstrual period. By maintaining the uterine lining, hCG provides a place for embryonic development. The embryo is totally dependent on the uterine lining until the placenta is fully formed, usually during the fourth month of pregnancy.

How does hCG work?

Once bound to the cells, it sends signals to cells across the cell membrane. The hormone isn't produced by all adults. Instead, embryonic cells begin producing hCG shortly after a woman conceives. Once the embryonic cells differentiate into tissue types, the tissues of the placenta take over hCG production.

Why is hCG important?

The hormone has an important role in both the detection and the maintenance of pregnancy. Pregnant women have very high hCG levels, but nonpregnant women and men do not have the hormone in their bloodstreams.

What is the purpose of hCG?

Learn More. The purpose of hCG is to maintain an important temporary maternal endocrine cell group called the corpus luteum. If an egg isn't fertilized, its corpus luteum dies within about 14 days. In the case of fertilization, hCG maintains the corpus luteum.

When is the placenta fully formed?

The embryo is totally dependent on the uterine lining until the placenta is fully formed, usually during the fourth month of pregnancy.

Can a pregnancy test detect hCG?

Learn More. Although hCG's primary role in pregnancy relates to the developing embryo, it has a separate utility—physicians can test for hCG levels in blood to monitor the viability of an early pregnancy. Also, home pregnancy tests can detect hCG in urin e ...

How does HCG help with pregnancy?

1. The levels of hCG in a pregnant person’s blood rise rapidly, doubling every two to three days. This is known as hCG doubling time.

What is the HCG hormone?

When your physician talks about hCG, they are referring to human chorionic gonadotropin —"the pregnancy hormone" produced by the placenta. The presence of hCG helps confirm pregnancy.

What does it mean when your HCG is slow?

Slow-rising hCG doubling times can be a sign of miscarriage or a symptom of ectopic pregnancy , but this is not always the case. The two- to three-day doubling guideline holds true in 85% of normal pregnancies. That means that about 15% of viable pregnancies may have slower hCG doubling times. 1.

How long after your period can you check if your hCG is doubling?

What hCG Doubling Times Can Show. Checking hCG doubling times is a good way to monitor whether a pregnancy is progressing normally until about six or seven weeks after your last menstrual period.

How long does it take for a quantitative hCG test to detect pregnancy?

A quantitative test (a.k.a. a beta hCG test) can detect the hormone sooner, about 11 days after you conceive. For a quantitative test, hCG is measured in milli-international units per milliliter (miU/ml). An hCG level above 5 mIU/ml is a positive indicator of pregnancy.

When does hCG peak?

Levels peaks during the first eight to 11 weeks of pregnancy , then decline and plateau. 5. Expected hCG levels in the first trimester are as follows. 3 However, know that there is a very wide range of normal hCG levels that are perfectly healthy.

Is hCG doubling time justified?

This is known as hCG doubling time. When this does not occur as expected, it could be cause for concern. 2. This concern does sometimes prove to be justified. However, women with low numbers can go on to have normal pregnancies and healthy babies. 2.

The role of hCG in pregnancy

Also known as the pregnancy hormone, hCG is produced by the cells surrounding a developing embryo that eventually go on to form the placenta. Production of this hormone kicks in almost immediately after implantation and levels increase rapidly during the early weeks of pregnancy.

Normal hCG levels

Human chorionic gonadotropin is produced naturally by the pituitary gland and occurs in both males and females throughout their lives. However, because of its key role in pregnancy, hCG production is at its highest during the first trimester of pregnancy and typically follows an exponential rise.

Low hCG levels

Low hCG levels are not always a cause for concern. Although the doubling guideline holds true in 85% of normal pregnancies, not all pregnancies follow this pattern and almost 8% of viable intrauterine pregnancies exhibited a slower rate of hCG rise.

Low hCG and miscarriage

Unfortunately, one of the reasons for slow rising hCG could be a miscarriage. If your hCG levels fail to rise or even go down, your doctor may be concerned about the viability of the pregnancy. Other blood tests may be ordered and your doctor will likely want to perform a transvaginal ultrasound to check for any other issues.

Tracking hCG levels

A blood test is the most accurate way to detect and track hCG levels and home pregnancy tests detect the hormone but can’t tell you the amount of hCG in your urine . And while some pregnancy tests on the market are geared to tell you if your hormone levels have risen over the baseline, they are not meant to monitor healthy pregnancies.

About Katerina Shkodzik

Dr. Katerina Shkodzik is a certified OB-GYN with a special focus on reproductive endocrinology and infertility issues. She has been practicing since 2015.

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Overview

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Human chorionic gonadotropin (hCG) is a hormone produced by your placenta once an embryo implants in the uterus. The purpose of the hormone is to tell your body to continue to produce progesterone, which prevents menstruation from occurring. This protects the endometrial uterine lining and your pregnancy. A mis…
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Diagnosis

  • A pregnancy test can detect hCG in your urine if your levels are high enough. This is how the test identifies that you are pregnant. But only a blood test can give you a precise numerical hCG reading. Typically, the gestational age of your baby is calculated by the date of your last menstruation. This can be easily miscalculated, particularly if you have a history of irregular peri…
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Results

  • The table below gives you a guideline as to the normal wide range of hCG levels in each week of pregnancy. hCG levels are measured in milli-international units of hCG hormone per milliliter of blood (mIU/mL). hCG levels usually consistently rise until around week 1012 of your pregnancy, when the levels plateau or even decrease. This is the reason why pregnancy symptoms can be g…
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Effects

  • In early pregnancy, hCG levels usually double every two to three days. Interestingly, when the measurements start off high they dont expand at the same rate. If they start off more slowly, the increase ends up happening much quicker.
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Causes

  • If your hCG levels fall below the normal range, its not necessarily a cause for concern. Many women have gone on to have healthy pregnancies and babies with low hCG levels. Most women dont ever have cause to find out what their hCG levels are specifically. However, sometimes low hCG levels can be caused by an underlying problem. This is when an egg is fertilized and attach…
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Symptoms

  • An ectopic pregnancy is when the fertilized egg remains in the fallopian tube and continues to develop. Its a dangerous and life-threatening condition, as it may cause the fallopian tube to rupture and bleed excessively. Low hCG levels can help to indicate an ectopic pregnancy. At first the symptoms of an ectopic pregnancy can be similar to those of a normal pregnancy, but as it …
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Treatment

  • Unfortunately, there is nothing that can be done to treat low hCG levels, though low levels alone are not always a cause for concern. If your low hCG levels have been caused by a miscarriage, its possible that you may need treatment if any pregnancy tissue is left inside your womb. If theres no tissue retained, then you wont require any treatment at all. If there is, then there are three trea…
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