Which description is consistent with acute lymphocytic leukemia (ALL)? A. ALL is a progressive neoplasm defined by the presence of greater than 30% lymphoblasts in the bone marrow or blood.
The common feature of all forms of leukemia is an uncontrolled proliferation of malignant leukocytes, causing an overcrowding of bone marrow and decreased production and function of normal hematopoietic cells. The two major forms of leukemia, acute and chronic, are classified by which criteria?
At the time of diagnosis, the individual usually has the classic triad of symptoms: fever, pharyngitis, and lymphadenopathy of the cervical lymph nodes. Early detection of acute leukemia would include which of the following symptoms?
Anorexia can occur in all varieties of acute leukemia and is associated with weight loss. Pain in the bones and joints is thought to result from leukemia infiltration with secondary stretching of the periosteum. What are the most significant risk factors for the development of thrombus formation as referred to by the Virchow triad?
The common feature of all forms of leukemia is an uncontrolled proliferation of malignant leukocytes, causing an overcrowding of bone marrow and decreased production and function of normal hematopoietic cells.
The current classification of leukemia is based on (1) the predominant cell of origin (either myeloid or lymphoid) and (2) the rate of progression, which usually reflects the degree at which cell differentiation was arrested when the cell became malignant (acute or chronic) (see Figure 29-2) .
As the immature blasts increase, they replace normal myelocytic cells, megakaryocytes, and erythrocytes. C. B cells fail to mature into plasma cells that synthesize immunoglobulins.
A. ALL is a progressive neoplasm defined by the presence of greater than 30% lymphoblasts in the bone marrow or blood. B. Leukocytosis and a predominance of blast cells characterize the bone marrow and peripheral blood.
Hodgkin disease is characterized by its progression from one group of lymph nodes to another, the development of systemic symptoms, and the presence of RS cells (see Figure 29-8), . but not the involvement of the Philadelphia chromosome. Virchow triad is a symptom related to thrombus formation.
Endotoxin, in particular, triggers the release of multiple cytokines that play a significant role in the development and maintenance of DIC. Proinflammatory cytokines—TNF-α; IL-1, IL-6, IL-8; PAF—are responsible for the clinical signs and symptoms associated with the sepsis associated with DIC.
The Philadelphia chromosome is present in more than 95% of patients with chronic myelogenous leukemia. Bence Jones protein. Multiple myeloma . The myeloma may produce free immunoglobulin light chain (Bence Jones protein) that is present in the blood and urine in approximately 80% of patients.