Minocycline is especially useful for treating tick-borne bacterial diseases such as Rocky Mountain spotted fever, ehrlichiosis and water-borne infections such as leptospirosis . Minocycline is also used to treat Wolbachia, an organism that infects heartworms, in an effort to treat heartworm disease. Minocycline is not effective for treating ...
Minocycline will inhibit the synthesis of protein within susceptible organisms (bacteria, etc.), resulting in their death. Minocycline is often used for infections caused by bacteria and by microorganisms that are not susceptible to common antibiotics.
Minocycline, also known as Minocin® or Dynacin®, is an antibiotic for dogs and cats of the tetracycline class. This drug is related to other tetracyclines such as doxycyline, chlortetracycline and oxytetracycline.
Minocycline is also used to treat Wolbachia, an organism that infects heartworms, in an effort to treat heartworm disease. Minocycline is not effective for treating infections caused by a virus or fungus.
Precautions and Side Effects. While generally safe and effective when prescribed by a veterinarian , minocycline can cause side effects in some animals. Minocycline should not be used in animals with known hypersensitivity or allergy to the drug. Minocycline may interact with other medications.
Minocycline may interact with other medications . Consult with your veterinarian to determine if other drugs your pet is receiving could interact with minocycline. Such drugs include certain antacids, iron supplements, kaolin, bismuth subsalicylate, isotretinoin, warfarin and certain antibiotics such as penicillins.
Minocycline may bind to calcium in teeth and cause discoloration. Therefore, the administration of minocycline to animals younger than seven months of age is discouraged without first consulting with a veterinarian. Minocycline is less likely to cause bone and teeth abnormalities then other tetracyclines.
There is some research that suggests that oral minocycline may have superior bioavailability and reach higher tissue-concentrations in horses when compared to oral doxycycline. There is a great deal of research interest in the use of both doxycycline and minocycline for the treatment of osteoarthritis in performance horses.
Minocycline is used in horses to treat susceptible bacterial infections and tick-borne diseases such as Ehrlichia, Anaplasma, and Borrelia burgdorferi (Lyme disease). There is some research that suggests that oral minocycline may have superior bioavailability and reach higher tissue-concentrations in horses when compared to oral doxycycline.
Minocycline is a semi-synthetic tetracycline antibiotic that has many similarities with doxycycline. Minocycline may be used orally (dogs, cats, and horses) or intravenously (dogs and cats). Tetracycline antibiotics are broad spectrum and bacteriostatic. Their mechanism of action is through the inhibition of protein synthesis and the alteration ...
Minocycline has increased penetration into bacterial cells and increased pharmacologic activity when compared to tetracycline. It is effective against a broad spectrum of gram-negative and gram-positive bacteria, and a wide variety of other organisms including Rickettsia, Spirochetes, Mycoplasma, and Chlamydia.
In addition to its use as an antibiotic, minocycline is used in low doses as an anti-inflammatory and adjunct treatment for arthritis and degenerative joint disease ...
Dr. Barbara Forney is a veterinary practitioner in Chester County, Pennsylvania. She has a master's degree in animal science from the University of Delaware and graduated from the University of Pennsylvania School of Veterinary Medicine in 1982.
Minocycline is a broad spectrum antibiotic which is effective for use against a wide variety of bacteria and other types of organisms. It is particularly useful for some of the more unusual types of infections, including those carried by ticks. Minocycline is available in oral and intravenous forms. Oral minocycline reaches high concentrations in most tissues in the body, even in difficult to penetrate areas such as joints, the prostate, the central nervous system, and the eyes. In addition to its use as an antibiotic, researchers are studying the use of low doses of minocycline as an anti-inflammatory in both dogs and horses with osteo-arthritis. Minocycline may be used in animals with decreased kidney function because it is eliminated primarily via the digestive tract.
General Drug Information and Indications. Minocycline is a broad spectrum antibiotic which is effective for use against a wide variety of bacteria and other types of organisms. It is particularly useful for some of the more unusual types of infections, including those carried by ticks.
Dr. Barbara Forney is a veterinary practitioner in Chester County, Pennsylvania. She has a master's degree in animal science from the University of Delaware and graduated from the University of Pennsylvania School of Veterinary Medicine in 1982.
Minocycline is a second-generation, semi-synthetic tetracycline that has been in therapeutic use for over 30 years because of its antibiotic properties against both gram-positive and gram-negative bacteria. It is mainly used in the treatment of acne vulgaris and some sexually transmitted diseases. Recently, it has been reported ...
(2009b), who reported its ability to prevent and treat dextran sodium sulphate-induced colitis, significantly diminishing the mortality rate and attenuating the severity of the disease.
Consistent with its anti-inflammatory properties, minocycline has been reported to act as a neuroprotective agent in models of both global and focal ischaemia, processes driven by the infiltration of the ischaemic brain area by inflammatory cells (Feuerstein et al., 1997; Koistinaho and Hökfelt, 1997).
This effect was associated with an induction of autophagic cell death, although minocycline still induced cell death through the activation of caspase-3 when autophagy was inhibited (Liu et al., 2011).
The pharmacological profile of tetracyclines, which combines anti-microbial with anti-inflammatory and anti-apoptotic properties, makes them suitable for periodontal disease treatment, which is characterized by an inflammatory process in addition to its well-known microbial aetiology (Soory, 2008).
IV: 200 mg IV initially followed by 100 mg IV every 12 hours#N#Maximum dose: 400 mg/24 hours#N#Oral:#N#Most infections: 200 mg orally initially followed by 100 mg orally every 12 hours#N#-Alternative regimen (if more frequent dosing preferred): 100 to 200 mg orally initially followed by 50 mg orally 4 times a day#N#Uncomplicated urethral, endocervical, or rectal infections due to Chlamydia trachomatis or Ureaplasma urealyticum: 100 mg orally every 12 hours for at least 7 days#N#Comments:#N#-With trachoma, infectious agent is not always eliminated (as assessed by immunofluorescence).#N#-Coadministration with streptomycin recommended for brucellosis.#N#-For syphilis, the duration of therapy is 10 to 15 days; close follow-up (including laboratory tests) recommended.#N#Uses:#N#-For the treatment of the following infections: Rocky Mountain spotted fever, typhus fever, typhus group, Q fever, rickettsialpox, tick fevers due to rickettsiae; respiratory tract infections due to Mycoplasma pneumoniae; lymphogranuloma venereum, trachoma, or inclusion conjunctivitis due to C trachomatis; psittacosis (ornithosis) due to Chlamydophila psittaci; nongonococcal urethritis, endocervical, or rectal infections due to U urealyticum or C trachomatis; relapsing fever due to Borrelia recurrentis; plague due to Yersinia pestis; tularemia due to Francisella tularensis; cholera due to Vibrio cholerae; Campylobacter fetus infections; brucellosis due to Brucella species; bartonellosis due to Bartonella bacilliformis; granuloma inguinale due to Klebsiella granulomatis#N#-For the treatment of infections due to the following bacteria when bacteriologic testing shows suitable susceptibility to this drug: Escherichia coli; Enterobacter aerogenes; Shigella species; Acinetobacter species; respiratory tract infections due to Haemophilus influenzae; respiratory tract and urinary tract infections due to Klebsiella species; upper respiratory tract infections due to Streptococcus pneumoniae#N#-When penicillin is contraindicated, as an alternative agent for the treatment of the following infections: Syphilis due to Treponema pallidum subspecies pallidum; yaws due to T pallidum subspecies pertenue; listeriosis due to Listeria monocytogenes; anthrax due to Bacillus anthracis; Vincent's infection due to Fusobacterium fusiforme; actinomycosis due to Actinomyces israelii; clostridial infections#N#-As adjunctive therapy for: Acute intestinal amebiasis; severe acne.
Extended-release formulations:#N#45 to 49 kg: 45 mg orally once a day#N#50 to 59 kg: 55 mg orally once a day#N#60 to 71 kg: 65 mg orally once a day#N#72 to 84 kg: 80 mg orally once a day#N#85 to 96 kg: 90 mg orally once a day#N#97 to 110 kg: 105 mg orally once a day#N#111 to 125 kg: 115 mg orally once a day#N#126 to 136 kg: 135 mg orally once a day#N#Duration of therapy: 12 weeks#N#Comments:#N#-Recommended dose is about 1 mg/kg once a day.#N#-This drug did not show any effect on non-inflammatory acne lesions.#N#-Safety not established beyond 12 weeks.#N#Use: To treat only inflammatory lesions of non-nodular moderate to severe acne vulgaris#N#American Academy of Dermatology (AAD) Recommendations:#N#Immediate-release formulations: 50 mg orally once to 3 times a day#N#Comments:#N#-Recommended as adjunctive treatment of moderate to severe inflammatory acne#N#-This drug should not be used as monotherapy.#N#-Use should be limited to the shortest duration possible; reevaluation recommended at 3 to 4 months to minimize resistant bacteria developing.#N#-Current guidelines should be consulted for additional information..
200 mg IV initially followed by 100 mg IV every 12 hours#N#Maximum dose: 400 mg/24 hours#N#Use: When penicillin is contraindicated, as an alternative agent for the treatment of meningitis due to Neisseria meningitidis
100 mg orally every 12 hours for 5 days#N#Comments:#N#-Diagnostic laboratory studies (including serotyping and susceptibility testing) are recommended to establish the carrier state and the appropriate therapy.#N#-Prophylactic use of this drug is only recommended when risk of meningococcal meningitis is high.#N#Use: In the treatment of asymptomatic carriers of N meningitidis to eliminate meningococci from the nasopharynx.
IV: 200 mg IV initially followed by 100 mg IV every 12 hours#N#Maximum dose: 400 mg/24 hours#N#Oral:#N#Infection due to Staphylococcus aureus: 200 mg orally initially followed by 100 mg orally every 12 hours#N#-Alternative regimen (if more frequent dosing preferred): 100 to 200 mg orally initially followed by 50 mg orally 4 times a day#N#Infection due to Mycobacterium marinum: 100 mg orally every 12 hours for 6 to 8 weeks#N#Comments:#N#-Not the drug of choice for any type of staphylococcal infection#N#-The optimal dose has not been established to treat M marinum infections; the recommended dose has been successful in limited cases.#N#Uses: For the treatment of skin and skin structure infections due to S aureus when bacteriologic testing shows suitable susceptibility to this drug; for the treatment of infections due to M marinum#N#Infectious Diseases Society of America (IDSA) Recommendations: 100 mg orally twice a day#N#Comments:#N#-Recommended for skin and soft tissue infections due to methicillin-susceptible and methicillin-resistant S aureus#N#-After an initial dose of 200 mg, recommended for purulent cellulitis (cellulitis associated with purulent drainage/exudate without a drainable abscess) due to methicillin-resistant S aureus#N#-Current guidelines should be consulted for additional information..
IV: 200 mg IV initially followed by 100 mg IV every 12 hours#N#Maximum dose: 400 mg/24 hours#N#Oral:#N#Infection due to Staphylococcus aureus: 200 mg orally initially followed by 100 mg orally every 12 hours#N#-Alternative regimen (if more frequent dosing preferred): 100 to 200 mg orally initially followed by 50 mg orally 4 times a day#N#Infection due to Mycobacterium marinum: 100 mg orally every 12 hours for 6 to 8 weeks#N#Comments:#N#-Not the drug of choice for any type of staphylococcal infection#N#-The optimal dose has not been established to treat M marinum infections; the recommended dose has been successful in limited cases.#N#Uses: For the treatment of skin and skin structure infections due to S aureus when bacteriologic testing shows suitable susceptibility to this drug; for the treatment of infections due to M marinum#N#Infectious Diseases Society of America (IDSA) Recommendations: 100 mg orally twice a day#N#Comments:#N#-Recommended for skin and soft tissue infections due to methicillin-susceptible and methicillin-resistant S aureus#N#-After an initial dose of 200 mg, recommended for purulent cellulitis (cellulitis associated with purulent drainage/exudate without a drainable abscess) due to methicillin-resistant S aureus#N#-Current guidelines should be consulted for additional information..
200 mg orally initially followed by 100 mg orally every 12 hours#N#-Alternative regimen (if more frequent dosing preferred): 100 to 200 mg orally initially followed by 50 mg orally 4 times a day#N#Use: For the treatment of chancroid due to H ducreyi