Vitamin K-dependent coagulation factors are synthesized in the liver. Consequently, severe liver disease results in lower blood levels of vitamin K-dependent clotting factors and an increased risk for uncontrolled bleeding (hemorrhage) (8).
The vitamin-K–dependent proteins, synthesized in the liver, play central roles in both the procoagulant or anticoagulant pathways.
Sources of Vitamin K However, the chief source of vitamin K is synthesis by bacteria in the large intestine, and in most cases, absence of dietary vitamin K is not at all deleterious. Vitamin K is a fat-soluble vitamin and both dietary and microbial vitamin K are absorbed into intestinal lymph along with other lipids.
Menaquinones (MKn, n = prenyl units in sidechain) are bacterially produced forms of vitamin K produced by the gut microbiota and consumed in the diet.
the liverMetabolism of vitamin K occurs mainly in the liver.
Vitamin K is found in: green leafy vegetables – such as broccoli and spinach. vegetable oils. cereal grains.
Menaquinones are the form of vitamin K that is produced by bacteria in the intestines. That means that digestion is of course not needed since this form of vitamin K does not enter the stomach. Menaquinones: are also absorbed by passive diffusion but it occurs in the ileum and colon.
Primarily in the liver.
Background: Phylloquinone is a prenylated naphthoquinone that is synthesized exclusively by plants, green algae, and some species of cyanobacteria, where it serves as a vital electron carrier in photosystem I and as an electron acceptor for the formation of protein disulfide bonds.
2) Menaquinone is synthesized by intestinal bacteria.
Menaquinones are the naturally occurring form of vitamin K identified in bacteria. Lipid extracts were made from three bacteria originally isolated from the human neonatal gut and identified as Enterobacter agglomerans, Serratia marcescens and Enterococcus faecium.
Vitamin K (vit K), a fat-soluble vitamin, exists in some forms: vit K1 (phylloquinone), which is mainly found in green leafy vegetables, and vit K2 (menaquinone-n: MK-n), which is mainly found in fermented dairy and produced by lactic acid bacteria in the intestine [1,2].