which of the following is true regarding the clinical course of chronic lymphocytic leukemia

The clinical course for patients with chronic lymphocytic leukemia (CLL) is diverse; some patients have indolent disease, never needing treatment, whereas others have aggressive disease requiring early treatment. We continue to use criteria for active disease to initiate therapy.

Full Answer

What are the key points of chronic lymphocytic leukemia?

Which of the following is true regarding the clinical course of chronic lymphocytic leukemia (CLL)?-aggressive disorder that presents with severe bleeding and anemia-benign disorder that rarely requires treatment-mild symptoms but usually fatal within 6 months-incurable but with a median survival of approximately 10 years

What is chronic lymphocytic leukemia?

Chronic lymphocytic leukemia (CLL) has an extended disease course in many patients. With a median age at diagnosis of 72 years, newer treatment options with less toxicity than standard nucleoside analogue-based regimens are needed. Historically, few therapy ...

What are the stages of chronic lymphocytic leukemia?

Abstract. A method of clinical staging of chronic lymphocytic leukemia (CLL) has been proposed which is based on the concept that CLL is a disease of progressive accumulation of nonfunctioning lymphocytes: stage O, bone marrow and blood lymphocytosis only; stage 1, lymphocytosis with enlarged nodes; stage II, lymphocytosis with enlarged spleen or liver or …

Is there a standard of care for chronic lymphocytic leukemia (CLL)?

What happens when CLL progresses?

In rare cases, CLL develops into a high-grade non-Hodgkin lymphoma. This condition is called Richter's syndrome, or a Richter transformation, and if this happens, it usually develops into a diffuse large B-cell lymphoma (DLBCL), which is treated like a lymphoma.

What cells are affected by chronic lymphocytic leukemia?

Chronic lymphocytic leukemia (CLL) is a type of cancer that starts in white blood cells (called lymphocytes) in the bone marrow. CLL mainly affects older adults and accounts for about one-third of all leukemias.

What is CLL chronic lymphocytic leukemia?

Chronic lymphocytic leukemia is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). Chronic lymphocytic leukemia (also called CLL) is a cancer of the blood and bone marrow that usually gets worse slowly. CLL is one of the most common types of leukemia in adults.Mar 4, 2022

Which of the following is most commonly seen in patients with chronic lymphoid leukemia CLL?

The most common symptom is enlarged lymph nodes, most often in the neck, armpit, or groin areas (figure 1). Less commonly, people with CLL notice other symptoms, including fatigue, unintentional weight loss, chronic fever (without other signs of infection), or night sweats.Aug 9, 2021

What is the main cause of chronic lymphocytic leukemia?

The exact cause of chronic lymphocytic leukemia is not known. Multiple genetic mutations occur in the DNA of blood-producing cells. These mutations cause the blood cells to produce abnormal lymphocytes, which are not effective at fighting infection. Usually, an abnormal chromosome is present in a patient with CLL.

What is chronic lymphocytic lymphoma?

Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults. It's a type of cancer that starts in cells that become certain white blood cells (called lymphocytes) in the bone marrow. The cancer (leukemia) cells start in the bone marrow but then go into the blood.May 10, 2018

Why is CLL called chronic?

Chronic lymphocytic leukemia (CLL) is a type of cancer of the blood and bone marrow — the spongy tissue inside bones where blood cells are made. The term "chronic" in chronic lymphocytic leukemia comes from the fact that this leukemia typically progresses more slowly than other types of leukemia.Aug 10, 2021

What is the most effective treatment for CLL?

For years, the standard treatment for CLL has been a combination of chemotherapy (fludarabine [Fludara]/cyclophosphamide [Neosar]) and targeted therapy (rituximab [Rituxan]). Most older adults, though, are unable to tolerate standard treatment because of severe, even life-threatening, side effects.Jan 20, 2015

Which diagnostic test result will the nurse expect when a patient is admitted with chronic lymphocytic leukemia CLL )?

Diagnosis. Patients with CLL have a higher-than-normal white blood cell count, which is determined by complete blood count (CBC). Peripheral blood flow cytometry is the most valuable test to confirm a diagnosis of CLL.

What are the four stages of CLL?

What are the stages of CLL?Stage 0. The blood has too many white blood cells called lymphocytes. This is called lymphocytosis. ... Stage I. The blood has too many lymphocytes. ... Stage II. The blood has too many lymphocytes. ... Stage III. The blood has too many lymphocytes. ... Stage IV. The blood has too many lymphocytes.

What is the difference between CLL and CML?

In CLL, the abnormal cells develop from early blood cells called the lymphoid blood stem cells. The cancerous white blood cells are B lymphocytes, also called B cells. In CML, the abnormal leukaemia cells develop from early blood cells called the myeloid blood stem cells.