Which description is consistent with acute lymphocytic leukemia (ALL)? A. ALL is a progressive neoplasm defined by the presence of greater than 30% lymphoblasts in the bone marrow or blood.
The common feature of all forms of leukemia is an uncontrolled proliferation of malignant leukocytes, causing an overcrowding of bone marrow and decreased production and function of normal hematopoietic cells. The two major forms of leukemia, acute and chronic, are classified by which criteria?
At the time of diagnosis, the individual usually has the classic triad of symptoms: fever, pharyngitis, and lymphadenopathy of the cervical lymph nodes. Early detection of acute leukemia would include which of the following symptoms?
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The Philadelphia chromosome is present in more than 95% of patients with chronic myelogenous leukemia. Bence Jones protein. Multiple myeloma . The myeloma may produce free immunoglobulin light chain (Bence Jones protein) that is present in the blood and urine in approximately 80% of patients.
C. B cells fail to mature into plasma cells that synthesize immunoglobulins.
A. ALL is a progressive neoplasm defined by the presence of greater than 30% lymphoblasts in the bone marrow or blood. B. Leukocytosis and a predominance of blast cells characterize the bone marrow and peripheral blood.
Endotoxin, in particular, triggers the release of multiple cytokines that play a significant role in the development and maintenance of DIC. Proinflammatory cytokines—TNF-α; IL-1, IL-6, IL-8; PAF—are responsible for the clinical signs and symptoms associated with the sepsis associated with DIC.
Heparin is a common cause of drug-induced thrombocytopenia. HIT is an immune-mediated, adverse drug reaction caused by immunoglobulin G antibodies that leads to increased platelet consumption and a decrease in platelet counts.
Local symptoms caused by pressure and obstruction of the lymph nodes are the result of lymphadenopathy.
D. The translocation of genetic material from genes 9 and 22 creates an abnormal, fused protein identified as BCR-ABL.