which cells are primary targets for hiv course hero
by Prof. Jay Armstrong
Published 1 year ago
Updated 1 year ago
9 min read
While the “immune privileged” CNS is largely devoid of CD4+ T cells, macrophage and microglia are abundant throughout the CNS. These cells likely express CD4 densities that are too low to facilitate efficient entry or allow sustained replication by most HIV-1 isolates.
Macrophages are important target cells for the Human Immunodeficiency Virus Type I (HIV-1
HIV-1
Abstract. Two HIV virus types exist: HIV-1 is pandemic and aggressive, whereas HIV-2 is confined mainly to West Africa and less pathogenic. Despite the fact that it has been almost 40 years since the discovery of AIDS, there is still no cure or vaccine against HIV.
Structure and genome. HIV is different in structure from other retroviruses. ...
Tropism. The term viral tropism refers to the cell types a virus infects. ...
Replication cycle. Mechanism of viral entry: 1. Initial interaction between gp120 and CD4. ...
Genetic variability. HIV differs from many viruses in that it has very high genetic variability. ...
What cells does HIV target?
HIV and T-helper Cells
Attachment and Entry. The HIV envelope contains specialized protein stems onto which a set of glycoproteins called gp120 are attached.
Reverse Transcription and Integration. ...
Protein Synthesis. ...
Packaging and Budding. ...
What is the host cell for HIV?
Understanding the HIV Life Cycle
Viral Attachment. Once HIV enters the body (typically through sexual contact, blood exposure, or mother-to-child transmission), it seeks out a host cell in order to reproduce.
Binding and Fusion. ...
Viral Uncoating. ...
Transcription and Translation. ...
Integration. ...
Assembly. ...
Maturation and Budding. ...
How does HIV infect cells?
HIV attacks human immune cells, but stem cell transplants help ... from adult donors who carried a mutation that blocks HIVinfection. Besides eventually eradicating the disease, the procedure ...
What cells are the primary target of HIV?
CD4+ T cells Given that CD4+ memory T cells are the primary target of HIV-1 in the blood (Brenchley et al.
What are target cell receptors for HIV?
Although CD4+ T cells are well known as the major HIV target, with infection occurring through the canonical combination of the cluster of differentiation 4 (CD4) receptor and either the C-C chemokine receptor type 5 (CCR5) or C-X-C chemokine receptor type 4 (CXCR4) coreceptors, HIV has also been found to enter other ...