Types of cell injury:Reversible injury. Reversible Injury Ischemic Cell Damage.Irreversible injury Irreversible Injury Ischemic Cell Damage (leads to cell death)
Hypoxia is the most important cause of cell injury. Irreversible cell injury can be recognized by changes in the appearance of the nucleus and rupture of the cell membrane.
There are two types of cell death, necrosis and apoptosis, which differ in their morphology, mechanisms, and roles in disease and physiology. When damage to membranes is severe, lysosomal enzymes enter the cytoplasm and digest the cell, and cellular contents leak out, resulting in necrosis.
Cellular damage after injury or damage Cellular damage causes a severe inflammatory response that ends with repair to damaged cells/tissue, and is part of the innate immune response. Following injury, the damaged endothelium releases mediators and stimulates the clotting cascade.
Hypoxia is the most common cause of cellular injury and can be initiated by decreased oxygen in the environment, decreased hemoglobin, decreased red blood cells, or cardiovascular collapse.
Causes of cell injuryOxygen deprivation. A hypoxic state results in reduced aerobic oxidative respiration, which results in cell injury. ... Physical agents. ... Chemical agents and drugs. ... Immunologic reactions. ... Infectious agents. ... Nutritional imbalances. ... Genetic derangement. ... Hypoxia and ischemic cell injury.
Terms in this set (21)Oxygen deprivation.physical injury.Chemical injury.Infectious agents.Nutritional imbalances.Genetic.
reversible cell injuryplasma membrane alterations.mitochondrial changes.dilation of the endoplasmic reticulum.nuclear alterations.cellular injury.Robbins.
Cell injury may be a reversible or irreversible process. In reversible cell injury, cells can recover to their normal function. In irreversible cell injury, cells undergo injury so severe that cell death and, ultimately, necrosis of tissue occur.
Term: cellular response to stimulus. Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.)
Mediators Released from Damaged Cells Provoke Pain This observation indicates that soluble factors released from damaged cells can directly activate neighboring primary afferents, acting in a paracrine fashion.