cascade. Clot promotion is not caused by vasoconstriction of the endothelium, or age-related changes that weaken the en dothelium. This process occurs in the intima of the artery.
Diabetes leads to endothelial damage, thickening of vessel walls, increased inflammation and leukocyte adhesion, increased. thrombosis, glycation of vascular proteins, and decreased production of endothelial-derived vasodilators such as nitric oxide. Diabetes is also associated with dyslipidemia.