what is the typical time course of change to specific endpoints based on route of administration

What is the endpoint name field in Digital Twins?

How do event routes work?

What is it called when an endpoint can't deliver an event?

What is an event route?

What is the event message in a compute resource?

Does a storage endpoint turn on dead lettering?

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Which routes of administration have the fastest and slowest rates of absorption?

As muscles are rich in large blood vessels, the absorption rate is faster than subcutaneous and intradermal routes. Oily, irritant and slow-releasing preparations can be given by intramuscular route. The disadvantage of this route is it may lead to nerve or vein damage.

How does route of administration affect the onset and duration of drug action?

The route of administration of a medication directly affects the drug bioavailability, which determines both the onset and the duration of the pharmacological effect. The choice of route of administration may be influenced by many factors among which include: convenience. state of the patient.

What does the duration of action of the drug depend on for parenteral administration?

Duration of drug action depends on several factors: the absolute amount of drug given; the pharmaceutical preparation; the reversibility of drug action; the half-life of the drug; the slope of the concentration-response curve; the activity of metabolites, and the influence of disease on drug elimination.

How is the route of administration of medication determined?

A medication administration route is often classified by the location at which the drug is applied, such as oral or intravenous. The choice of routes in which the medications are applied depends not only on the convenience but also on the drug's properties and pharmacokinetics.

Which route of administration has the quickest onset of action?

The intravenous route provides immediate onset of action. The intramuscular and subcutaneous routes can be used to achieve slow or delayed onset of action. Patient compliance problems are largely avoided .

Which route of drug administration is most likely to lead to the first-pass effect?

Oral route of drug administration is most likely to lead to the first-pass effect.

Which of the following routes of drug administration would be the fastest way for a drug to reach the brain?

The fastest way to get a drug to the brain is by smoking it. When a drug like tobacco smoke is taken into the lungs, nicotine (the addictive chemical in tobacco) seeps into lung blood where it can quickly travel to the brain.

What is the duration of action of drugs?

The duration of action of a drug is the length of time that particular drug is effective. Duration of action is a function of several parameters including plasma half-life, the time to equilibrate between plasma and target compartments, and the off rate of the drug from its biological target.

How much time does an intravenous administered drug take to complete a circulation?

Pharmacokinetics: With IV administration, onset is usually within 1 minute, with a peak at 2 to 6 minutes and recovery within 30 to 60 minutes. With PO administration, onset is 15 to 20 minutes, with recovery in 60 to 90 minutes.

Which route of administration is used most often Why?

Oral route Many drugs can be administered orally as liquids, capsules, tablets, or chewable tablets. Because the oral route is the most convenient and usually the safest and least expensive, it is the one most often used. However, it has limitations because of the way a drug typically moves through the digestive tract.

What is the fastest route of absorption for a drug?

Intravenous (IV) It is the fastest and most certain and controlled way. It bypasses absorption barriers and first-pass metabolism. It is used when a rapid effect is required, continuous administraction and large volumes.

What is the fastest route of drug administration quizlet?

The intravenous route is the fastest acting of all the routes of medication administration.

How does route of administration affect drug action?

Since the bioavailability of a drug is directly dependent on the rate and extent of drug absorption at the site of administration, factors affecting drug absorption, including the route of administration directly affect the bioavailability of that drug.

What determines the onset of action of a drug?

The determination of the onset of action, however, is not completely dependent upon route of administration. There are several other factors that determine the onset of action for a specific drug, including drug formulation, dosage, and the patient receiving the drug.

Why is it important to administer a medication by the proper route?

Taking a dose too soon could lead to drug levels that are too high, and missing a dose or waiting too long between doses could lower the amount of drug in your body and keep it from working properly.

How does route of administration affect bioavailability?

By definition, when a medication is administered intravenously, its bioavailability is 100%. However, when a medication is administered via routes other than intravenous, its bioavailability is generally lower than that of intravenous due to intestinal endothelium absorption and first-pass metabolism.

What is routing preference?

Configuring routing preference gives you the flexibility to optimize your traffic either for premium network performance or for cost. When you configure a routing preference, you specify how traffic will be directed to the public endpoint for your storage account by default. You can also publish route-specific endpoints for your storage account.

What is Azure global network?

The Microsoft global network is optimized for low-latency path selection to deliver premium network performance with high reliability. Both inbound and outbound traffic are routed through the point of presence (POP) that is closest to the client. This default routing configuration ensures that traffic to and from your storage account traverses over the Microsoft global network for the bulk of its path, maximizing network performance.

Can Azure Storage publish endpoints?

You can also publish route-specific endpoints for your storage account. When you publish route-specific endpoints, Azure Storage creates new public endpoints for your storage account that route traffic over the desired path. This flexibility enables you to direct traffic to your storage account over a specific route without changing your default ...

Can you copy a connection string?

The connection strings for the published route-specific endpoints can be copied via the Azure portal. These connection strings can be used for Shared Key authorization with all existing Azure Storage SDKs and APIs.

What is endpoint routing in ASP.NET?

Endpoint routing allows ASP.NET Core applications to determine the endpoint that will be dispatched, early on in the middleware pipeline, and so makes the framework more flexible.

What is ASP.NET Core 3.0?

ASP.NET Core 3.0 brings a new concept of Endpoint routing which provides routing information to middlewares in the Startup.cs class. This feature was not there in the ASP.NET Core 2.0 and earlier versions. To understand it, see the below code that tries to find out the Controller’s name, in the Configure method of the Startup.cs file.

Why is endpoint routing important in ASP.NET?

Endpoint routing makes the ASP.NET Core framework more flexible since it decouples the route matching and resolution functionality from the endpoint dispatching functionality , which until now was all bundled in with the MVC middleware.

Does ASP.NET 3.0 have endpoint routing?

By default the ASP.NET 3.0 and later versions have Endpoint routing enabled. You only have to add app.UseRouting () ’ in the Configure () method of the Startup.cs file, before any other middleware that needs to access routing:

Is routing decoupled from ASP.NET?

The new thing is that the routing is decoupled from the specific ASP.NET Feature. In the previous Versions, every feature (MVC, Razor Pages, SIgnalR, etc.), had it’s own endpoint implementation. Now the endpoint and routing configuration can be done independently.

Is ASP.NET Core Model Validation easy?

The process of implementing ASP.NET Core Model Validation is never been so easy if you check out this tutorial.

What is traffic manager subnet routing?

For example, using subnet routing, a customer can route all requests from their corporate office to a different endpoint, where they might be testing an internal-only version of the app. Another scenario is if you want to provide a different experience to users who connect from a specific ISP (for example, to block users from a specific ISP).

What is traffic manager?

Traffic Manager profile contains a prioritized list of service endpoints. By default, Traffic Manager sends all traffic to the primary (highest-priority) endpoint. If the primary endpoint isn’t available, Traffic Manager routes the traffic to the second endpoint. If both the primary and secondary endpoints are not available, the traffic goes to the third endpoint, and so on. Availability of the endpoint is based on the configured status (enabled or disabled) and the ongoing endpoint monitoring that is set up.

What is geographic routing?

With the geographic routing method, users are directed to specific endpoints based on where their DNS query originates. Using this method enables you to geo-fence content to specific user regions. For example, European users can be directed to an endpoint in Europe that has specific terms and conditions for regional compliance. Users in China can be directed to an endpoint that has been localized in Mandarin.

What is the routing method used to determine the best endpoint?

To choose the best endpoint to use, this routing method uses an internet latency table, which actively tracks network latency to the endpoints from locations around the globe. When a user makes a request, Traffic Manager returns the best performing endpoint based on the location of the request.

Why use multivalue routing?

You can use the multivalue routing method to get multiple healthy endpoints in a single DNS query response. The caller can make client-side retries with other endpoints if an endpoint is unresponsive. This pattern can increase the availability of a service and reduce the latency associated with a new DNS query to obtain a healthy endpoint.

What is performance routing?

Performance routing. Performance traffic routing method connects users with the server that performs best for the user. If you have endpoints in different geographic locations, you can use performance routing to send users to the endpoint that has the best performance for the user. It might be better performing because it’s physically closer to ...

How many methods does traffic manager use?

Traffic Manager applies a traffic routing method to each DNS query it receives and determines which endpoint is returned in the response. You can choose from six traffic routing methods.

What is ASP.NET Core Convention based routing?

ASP.NET Core Convention based routing is typically used with the MVC controllers ( i.e. Controller with views). It configures set of Endpoints based on conventions of URL Patterns. We configure these conventions in the UseEndpoints method in the Configure method of startup class.

What is URL pattern?

The Each Route contains a Name, URL Pattern , Defaults and Constraints. The URL Pattern is compared to the incoming URLs for a match. An example of URL Pattern is {controller=Home}/ {action=Index}/ {id?}

Why does the URL www.example.com/product only have one segment?

This is because the action placeholder has a default value of the Index. if there is no corresponding segments are in the URL and segment has a default value in the Pattern, then the default value is chosen by the Routing Engine.

What is convention based routing?

The Convention based Routing uses the a set of conventions to specify the URL Pattern. The URL Pattern is then used to map URL paths into controller action method.

What is a pattern in routing?

Each route must contain a URL Pattern. This Pattern is compared to an incoming URL. If the pattern matches the URL, then it is used by the routing system to process that URL.

Why does the URL www.example.com/product/list/10/detail fail?

The URL www.example.com/product/list/10/detail fails. That is because this URL has four segments and the URL Pattern has three.

What is the difference between MVC and API controllers?

The Controller class itself inherits from ControllerBase class and adds functions that are needed to support views. The API Controllers are expected to return data in serialized to format, While MVC Controllers are expected return views. Apart from that, there is not much difference between them.

What is the endpoint name field in Digital Twins?

This endpointName field identifies an endpoint such as an Event Hub, Event Grid, or Service Bus. These endpoints must be created in your subscription and attached to Azure Digital Twins using control plane APIs before making this registration call.

How do event routes work?

Event routes are also used to handle events within the twin graph and send data from digital twin to digital twin. This is done by connecting event routes through Event Grid to compute resources, such as Azure Functions. These functions then define how twins should receive and respond to events.

What is it called when an endpoint can't deliver an event?

This process is known as dead-lettering . Azure Digital Twins will dead-letter an event when one of the following conditions is met.

What is an event route?

An event route lets you send event data from digital twins in Azure Digital Twins to custom-defined endpoints in your subscriptions. Three Azure services are currently supported for endpoints: Event Hub, Event Grid, and Service Bus. Each of these Azure services can be connected to other services and acts as the middleman, sending data along to final destinations such as TSI or Azure Maps for whatever processing you need.

What is the event message in a compute resource?

The event message also contains the ID of the source twin that sent the message, so the compute resource can use queries or traverse relationships to find a target twin for the desired operation .

Does a storage endpoint turn on dead lettering?

If either of the conditions is met, the event is dropped or dead-lettered. By default, each endpoint does not turn on dead-lettering. To enable it, you must specify a storage account to hold undelivered events when creating the endpoint. You can then pull events from this storage account to resolve deliveries.

Endpoint Routing Example

Implementing Endpoint Routing

Where to Use Endpoint Routing

How to Update Your Routes

• Updating your older routes to Endpoint routing is easy. Go to the Startup.cs file where your old routes are written. You only have to add all the routes inside the app.UseMvc() method to inside the endpoints.MapControllerRoute()method. See – However if you want to keep working with your old routes then you can disable the Endpoint routing from the ...

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