Wilms’ tumors can be observed to develop within a proportion of nephrogenic rests and in 40% of Wilms’ tumor patients nephrogenic rest can be identified (16, 18). Nephrogenic rests are thought to be the precursor lesions of Wilms’ tumors.
Full Answer
Wilms tumor is an embryonal renal neoplasm which contains blastemal, stromal or epithelial cell types. Wilms tumor is seen more in females than males, Whites more than Blacks and rarely in Asians. It makes up 6-7% of all childhood cancers. More than 80% are diagnosed before age 5 years.
Let’s talk about Etiology of Wilms There are different causes of Wilms tumors there are heredity or mutation of genes, familial which is autosomal dominant with low penetrance, possible parental work exposure.
P53 has been linked with anaplastic Wilms tumor. Signs and Symptoms Most patients present asymptomatic having a palpable abdominal mass either found by the parent or health care provider. Parents usually state that they noticed the child’s stomach getting bigger.
Unfavorable histology means diffuse anaplasia (extreme nuclear aplasia) is present in 5% of Wilms tumors. Even a small number of abnormal nuclei can worsen the prognosis in stage 2,3 and 4 tumors. Treatment Plans Treatment in North America is multifactorial.
Staging of Wilms Tumor is based on the spreading of the tumor. Stage 1- Tumor is limited to the kidney and is able to be totally removed. Stage 2- Tumor extended beyond the kidney no peritoneal involvement, can be Totally removed. Stage 3- No metastases but residual tumor remains in abdomen after surgery.
Stage 1- Tumor is limited to the kidney and is able to be totally removed. Stage 2- Tumor extended beyond the kidney no peritoneal involvement, can be Totally removed. Stage 3- No metastases but residual tumor remains in abdomen after surgery. Stage 4- Metastases are present usually to lung.
It is the fifth most common type of pediatric cancers. Wilms tumor is an embryonal renal neoplasm which contains blastemal, stromal or epithelial cell types. Wilms tumor is seen more in females than males, Whites more than Blacks and rarely in Asians. It makes up 6-7% of all childhood cancers.