Medical therapy in treatment of ORN is primarily supportive, involving nutritional support along with superficial debridement and oral saline irrigation for local wounds. Antibiotics are indicated only for definite secondary infection.
[ 14, 15] Most reconstructive surgeons currently use vascularized free tissue transfers instead of HBO therapy in the management of stage III ORN. Microvascular reconstruction.
Its use in the treatment of mandibular ORN is unknown, however. A study by Rogers et al indicated that the health-related quality of life is relatively poor in patients with severe ORN of the mandible who undergo composite resection.