Erythromycin is usually taken by mouth as tablets, capsules or as a liquid every 6 to 12 hours. The most important thing to keep people with gastroparesis healthy is making sure that they
Aim: To determine the optimal dosage form of erythromycin for use as a prokinetic agent. Methods: Eight normal volunteers and three patients with documented gastroparesis ingested 250 mg erythromycin in tablet. suspension and intravenous forms. Serum erythromycin levels were determined at frequent intervals.
Erythromycin appears to be both effective and well tolerated in clinical studies. At this time it should be reserved for the treatment of patients with diabetic gastroparesis who are resistant to or intolerant of other prokinetic agents. Future research on erythromycin's long-term safety and comparative efficacy will further define its role.
Box 3: Drug therapy in gastroparesis. Erythromycin. Intravenous 80–200 mg three times daily initially in severe cases. Oral suspension 200–300 mg before meals. Tachyphylaxis may occur. Drug interactions are common. Dopamine antagonists. Metoclopramide 10 …
Your doctor will advise you on how long to take erythromycin for (usually 5 to 10 days), but depending on the infection, it could be longer. Always take your erythromycin exactly as your doctor has told you.Feb 11, 2022
Erythromycin: This macrolide antibiotic has been available since the 1950s. It is rarely used as an antibiotic today and is primarily prescribed for its “prokinetic” effect on the gastrointestinal (GI) tract. It has been used successfully off-label for the treatment of gastroparesis and other GI hypomotility disorders.Feb 15, 2019
Low-dose erythromycin induced phase 3 of the MMC in 64.3% of patients and phase 3-like contractions in 21.4%. The injection of erythromycin significantly increased the frequency (2.8 ± 0.4/min) of phase 3 compared with the patients with spontaneous contractions (1.6 ± 0.3/min).
The Cause of the Gastroparesis Matters Patients with idiopathic post-viral gastroparesis usually improve over the course of time, ranging from several months to one or two years.
There's no cure for gastroparesis. It's a chronic, long-term condition that can't be reversed. But while there isn't a cure, your doctor can come up with a plan to help you manage symptoms and reduce the likelihood of serious complications.Sep 25, 2019
Although there's no cure for gastroparesis, changes to your diet, along with medication, can offer some relief.Oct 10, 2020
The most common side effects of erythromycin are feeling or being sick (nausea or vomiting), stomach cramps and diarrhoea. Drinking alcohol with erythromycin may slightly reduce or delay the medicine's benefits.Nov 26, 2018
Erythromycin also induced symptoms of upper abdominal pain, bloating, and nausea.
Changing eating habitseat foods low in fat and fiber.eat five or six small, nutritious meals a day instead of two or three large meals.chew your food thoroughly.eat soft, well-cooked foods.avoid carbonated, or fizzy, beverages.avoid alcohol.drink plenty of water or liquids that contain glucose and electrolytes, such as.More items...
Therapies that are used to treat individuals with gastroparesis include non-pharmacological steps, dietary modification, medications that stimulate gastric emptying (prokinetics), medications that reduce vomiting (antiemetics), medications for controlling pain and intestinal spasms, and surgery.
Prokinetic agents increase the rate of gastric emptying and decrease symptoms in patients with gastroparesis. Metoclopramide, a dopamine-2 receptor antagonist, is approved by the US Food and Drug Administration (FDA) for the treatment of gastroparesis.
Eating smaller meals. Increasing the number of daily meals and decreasing the size of each one can help alleviate bloating and possibly allow the stomach to empty more quickly.Chewing food properly. ... Avoiding lying down during and after meals. ... Consuming liquid meal replacements. ... Taking a daily supplement.
Symptoms from gastroparesis include nausea, vomiting, early satiety, postprandial fullness, bloating, and upper abdominal pain.
The most common adverse extrapyramidal side effects of metoclopramide are acute dystonias (incidence of 0.2% (81)). The incidence of acute dystonias in a UK series was higher in females, patients receiving higher doses, in children, and young adults. Whereas prolonged reactions were more common in elderly patients.
Postsurgical gastroparesis (PSG), often with vagotomy or vagus nerve injury, represents the third most common etiology of gastroparesis. In the past, most cases resulted from vagotomy performed in combination with gastric drainage to correct medically refractory or complicated peptic ulcer disease.
Gastroparesis can be associated with and may aggravate gastroesophageal reflux disease (GERD). Evaluation for the presence of gastroparesis should be considered in patients with GERD that is refractory to acid-suppressive treatment. (Conditional recommendation, moderate level of evidence) Recommendations.
Thus, botulinum toxin injection into the pylorus is not recommended as a treatment for gastroparesis (134), although there is a need for further study in patients with documented “pylorospasm.”. Table 6. Systematic review of studies on botulinum toxin injection into the pylori sphincter for treatment of gastroparesis.
If the patient responds favourably, treatment is then continued with erythromycin suspension given orally in due time, preferably 30–45 min before meals.
A wide range of dyspeptic symptoms are common in patients with gastroparesis—for example, nausea, vomiting, upper abdominal pain, abdominal distension and bloating. The individual symptoms have, in general, a low specificity to predict delayed emptying.
The term “gastroparesis” is a Greek word that means “a weakness of movement”. In this article, some basic facts about gastroparesis are briefly mentioned before aspects on therapy are discussed.
Macrolides are a group of substances, some of which have antibiotic properties and/or motilin receptor stimulation action in the GI tract, and thereby exert prokinetic effects. The first macrolide clinically explored was erythromycin, which, in early experiments, showed motility‐stimulating properties in dogs.
Sulpiride is a dopamine blocker used for some psychotic and other psychiatric disorders. This drug has prokinetic properties, but a pharmacological profile that is somewhat different from metoclopramide and domperidone, and has been studied in patients with dyspeptic symptoms.
In gastrointestinal (GI) practice, gastroparesis is common among patients with diabetes mellitus, and is reported to occur in 30–50% of the patients.5Another large group comprises patients with idiopathic gastroparesis in whom no underlying cause of the disorder can be found.
Erythromycin has active ingredients of erythromycin. It is often used in acne. eHealthMe is studying from 8,207 Erythromycin users for its effectiveness, alternative drugs and more.
Gastroparesis (delayed emptying of food from the stomach) is found to be associated with 4 conditions by eHealthMe.
You can use the report to supplement drug labels on your pill bottles or discuss it with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
The study is based on erythromycin (the active ingredients of Erythromycin) and Erythromycin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study neither.
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ORAL:#N#Erythromycin Base (Base) or Erythromycin Stearate (Stearate):#N#Mild to moderate infections: 250 mg orally every 6 hours, 333 mg orally every 8 hours, OR 500 mg orally every 12 hours#N#Severe infections: 1 gram orally every 6 hours#N#-Maximum dose: 4 grams/day#N#Erythromycin Ethylsuccinate (Ethylsuccinate): 400 mg orally every 6 hours#N#-Maximum dose: Up to 4 grams/day#N#PARENTERAL:#N#Erythromycin Lactobionate (Lactobionate): 15 to 20 mg/kg IV per day via intermittent IV infusion over 20 to 60 minutes no more than every 6 hours or via slow continuous IV infusion#N#-Maximum dose: 4 grams/day#N#Duration of therapy:#N#-Intestinal amebiasis: 10 to 14 days#N#-Streptococcal infections: At least 10 days#N#Comments:#N#-This drug should be taken approximately 1 hour prior to meals.#N#-Higher doses may be increased (up to 4 grams/day), depending on the severity of the infection.#N#-Ethylsuccinate formulations doses may be given every 12 hours in 2 divided doses OR every 8 hours in 3 divided doses if desired.#N#-Many strains of Haemophilus influenzae are not susceptible to concentrations of this drug typically achieved by dosing; concomitant dosing with sulfonamides should be used in patients with upper respiratory tract infections caused by H influenzae.#N#-Resistant staphylococcal skin infections may reemerge with treatment.#N#-Patients with extrahepatic amebiasis should be given treatment with other antibiotics.#N#-Parenteral formulations should be replaced by oral formulations as soon as possible.#N#Uses:#N#-As an adjunct to antitoxin to prevent the establishment of carriers and to eradicate the organism in carriers of diphtheria caused by Corynebacterium diphtheriae#N#-Treatment of erythrasma due to Corynebacterium minutissimum#N#-Treatment of listeriosis caused by Listeria monocytogenes#N#-Treatment of mild to moderate lower respiratory tract infections caused by Streptococcus pneumoniae (Diplococcus pneumoniae) or Streptococcus pyogenes (Group A beta-hemolytic streptococci [GAS])#N#-Treatment of mild to moderate skin and structure infections caused by Staphylococcus aureus or S pyogenes#N#-Treatment of mild to moderate upper respiratory tract infections caused by H influenzae (when used concomitantly with adequate doses of sulfonamides), S pneumoniae (D pneumoniae), or S pyogenes (GAS)#N#-Treatment of respiratory tract infections due to Mycoplasma pneumoniae#N#-Oral formulations: Treatment of intestinal amebiasis caused by Entamoeba histolytica.
ORAL:#N#Erythromycin Base (Base) or Erythromycin Stearate (Stearate):#N#Mild to moderate infections: 250 mg orally every 6 hours, 333 mg orally every 8 hours, OR 500 mg orally every 12 hours#N#Severe infections: 1 gram orally every 6 hours#N#-Maximum dose: 4 grams/day#N#Erythromycin Ethylsuccinate (Ethylsuccinate): 400 mg orally every 6 hours#N#-Maximum dose: Up to 4 grams/day#N#PARENTERAL:#N#Erythromycin Lactobionate (Lactobionate): 15 to 20 mg/kg IV per day via intermittent IV infusion over 20 to 60 minutes no more than every 6 hours or via slow continuous IV infusion#N#-Maximum dose: 4 grams/day#N#Duration of therapy:#N#-Intestinal amebiasis: 10 to 14 days#N#-Streptococcal infections: At least 10 days#N#Comments:#N#-This drug should be taken approximately 1 hour prior to meals.#N#-Higher doses may be increased (up to 4 grams/day), depending on the severity of the infection.#N#-Ethylsuccinate formulations doses may be given every 12 hours in 2 divided doses OR every 8 hours in 3 divided doses if desired.#N#-Many strains of Haemophilus influenzae are not susceptible to concentrations of this drug typically achieved by dosing; concomitant dosing with sulfonamides should be used in patients with upper respiratory tract infections caused by H influenzae.#N#-Resistant staphylococcal skin infections may reemerge with treatment.#N#-Patients with extrahepatic amebiasis should be given treatment with other antibiotics.#N#-Parenteral formulations should be replaced by oral formulations as soon as possible.#N#Uses:#N#-As an adjunct to antitoxin to prevent the establishment of carriers and to eradicate the organism in carriers of diphtheria caused by Corynebacterium diphtheriae#N#-Treatment of erythrasma due to Corynebacterium minutissimum#N#-Treatment of listeriosis caused by Listeria monocytogenes#N#-Treatment of mild to moderate lower respiratory tract infections caused by Streptococcus pneumoniae (Diplococcus pneumoniae) or Streptococcus pyogenes (Group A beta-hemolytic streptococci [GAS])#N#-Treatment of mild to moderate skin and structure infections caused by Staphylococcus aureus or S pyogenes#N#-Treatment of mild to moderate upper respiratory tract infections caused by H influenzae (when used concomitantly with adequate doses of sulfonamides), S pneumoniae (D pneumoniae), or S pyogenes (GAS)#N#-Treatment of respiratory tract infections due to Mycoplasma pneumoniae#N#-Oral formulations: Treatment of intestinal amebiasis caused by Entamoeba histolytica.
ORAL:#N#Erythromycin Base (Base) or Erythromycin Stearate (Stearate):#N#Mild to moderate infections: 250 mg orally every 6 hours, 333 mg orally every 8 hours, OR 500 mg orally every 12 hours#N#Severe infections: 1 gram orally every 6 hours#N#-Maximum dose: 4 grams/day#N#Erythromycin Ethylsuccinate (Ethylsuccinate): 400 mg orally every 6 hours#N#-Maximum dose: Up to 4 grams/day#N#PARENTERAL:#N#Erythromycin Lactobionate (Lactobionate): 15 to 20 mg/kg IV per day via intermittent IV infusion over 20 to 60 minutes no more than every 6 hours or via slow continuous IV infusion#N#-Maximum dose: 4 grams/day#N#Duration of therapy:#N#-Intestinal amebiasis: 10 to 14 days#N#-Streptococcal infections: At least 10 days#N#Comments:#N#-This drug should be taken approximately 1 hour prior to meals.#N#-Higher doses may be increased (up to 4 grams/day), depending on the severity of the infection.#N#-Ethylsuccinate formulations doses may be given every 12 hours in 2 divided doses OR every 8 hours in 3 divided doses if desired.#N#-Many strains of Haemophilus influenzae are not susceptible to concentrations of this drug typically achieved by dosing; concomitant dosing with sulfonamides should be used in patients with upper respiratory tract infections caused by H influenzae.#N#-Resistant staphylococcal skin infections may reemerge with treatment.#N#-Patients with extrahepatic amebiasis should be given treatment with other antibiotics.#N#-Parenteral formulations should be replaced by oral formulations as soon as possible.#N#Uses:#N#-As an adjunct to antitoxin to prevent the establishment of carriers and to eradicate the organism in carriers of diphtheria caused by Corynebacterium diphtheriae#N#-Treatment of erythrasma due to Corynebacterium minutissimum#N#-Treatment of listeriosis caused by Listeria monocytogenes#N#-Treatment of mild to moderate lower respiratory tract infections caused by Streptococcus pneumoniae (Diplococcus pneumoniae) or Streptococcus pyogenes (Group A beta-hemolytic streptococci [GAS])#N#-Treatment of mild to moderate skin and structure infections caused by Staphylococcus aureus or S pyogenes#N#-Treatment of mild to moderate upper respiratory tract infections caused by H influenzae (when used concomitantly with adequate doses of sulfonamides), S pneumoniae (D pneumoniae), or S pyogenes (GAS)#N#-Treatment of respiratory tract infections due to Mycoplasma pneumoniae#N#-Oral formulations: Treatment of intestinal amebiasis caused by Entamoeba histolytica.
ORAL:#N#Erythromycin Base (Base) or Erythromycin Stearate (Stearate):#N#Mild to moderate infections: 250 mg orally every 6 hours, 333 mg orally every 8 hours, OR 500 mg orally every 12 hours#N#Severe infections: 1 gram orally every 6 hours#N#-Maximum dose: 4 grams/day#N#Erythromycin Ethylsuccinate (Ethylsuccinate): 400 mg orally every 6 hours#N#-Maximum dose: Up to 4 grams/day#N#PARENTERAL:#N#Erythromycin Lactobionate (Lactobionate): 15 to 20 mg/kg IV per day via intermittent IV infusion over 20 to 60 minutes no more than every 6 hours or via slow continuous IV infusion#N#-Maximum dose: 4 grams/day#N#Duration of therapy:#N#-Intestinal amebiasis: 10 to 14 days#N#-Streptococcal infections: At least 10 days#N#Comments:#N#-This drug should be taken approximately 1 hour prior to meals.#N#-Higher doses may be increased (up to 4 grams/day), depending on the severity of the infection.#N#-Ethylsuccinate formulations doses may be given every 12 hours in 2 divided doses OR every 8 hours in 3 divided doses if desired.#N#-Many strains of Haemophilus influenzae are not susceptible to concentrations of this drug typically achieved by dosing; concomitant dosing with sulfonamides should be used in patients with upper respiratory tract infections caused by H influenzae.#N#-Resistant staphylococcal skin infections may reemerge with treatment.#N#-Patients with extrahepatic amebiasis should be given treatment with other antibiotics.#N#-Parenteral formulations should be replaced by oral formulations as soon as possible.#N#Uses:#N#-As an adjunct to antitoxin to prevent the establishment of carriers and to eradicate the organism in carriers of diphtheria caused by Corynebacterium diphtheriae#N#-Treatment of erythrasma due to Corynebacterium minutissimum#N#-Treatment of listeriosis caused by Listeria monocytogenes#N#-Treatment of mild to moderate lower respiratory tract infections caused by Streptococcus pneumoniae (Diplococcus pneumoniae) or Streptococcus pyogenes (Group A beta-hemolytic streptococci [GAS])#N#-Treatment of mild to moderate skin and structure infections caused by Staphylococcus aureus or S pyogenes#N#-Treatment of mild to moderate upper respiratory tract infections caused by H influenzae (when used concomitantly with adequate doses of sulfonamides), S pneumoniae (D pneumoniae), or S pyogenes (GAS)#N#-Treatment of respiratory tract infections due to Mycoplasma pneumoniae#N#-Oral formulations: Treatment of intestinal amebiasis caused by Entamoeba histolytica.
ORAL:#N#Erythromycin Base (Base) or Erythromycin Stearate (Stearate):#N#Mild to moderate infections: 250 mg orally every 6 hours, 333 mg orally every 8 hours, OR 500 mg orally every 12 hours#N#Severe infections: 1 gram orally every 6 hours#N#-Maximum dose: 4 grams/day#N#Erythromycin Ethylsuccinate (Ethylsuccinate): 400 mg orally every 6 hours#N#-Maximum dose: Up to 4 grams/day#N#PARENTERAL:#N#Erythromycin Lactobionate (Lactobionate): 15 to 20 mg/kg IV per day via intermittent IV infusion over 20 to 60 minutes no more than every 6 hours or via slow continuous IV infusion#N#-Maximum dose: 4 grams/day#N#Duration of therapy:#N#-Intestinal amebiasis: 10 to 14 days#N#-Streptococcal infections: At least 10 days#N#Comments:#N#-This drug should be taken approximately 1 hour prior to meals.#N#-Higher doses may be increased (up to 4 grams/day), depending on the severity of the infection.#N#-Ethylsuccinate formulations doses may be given every 12 hours in 2 divided doses OR every 8 hours in 3 divided doses if desired.#N#-Many strains of Haemophilus influenzae are not susceptible to concentrations of this drug typically achieved by dosing; concomitant dosing with sulfonamides should be used in patients with upper respiratory tract infections caused by H influenzae.#N#-Resistant staphylococcal skin infections may reemerge with treatment.#N#-Patients with extrahepatic amebiasis should be given treatment with other antibiotics.#N#-Parenteral formulations should be replaced by oral formulations as soon as possible.#N#Uses:#N#-As an adjunct to antitoxin to prevent the establishment of carriers and to eradicate the organism in carriers of diphtheria caused by Corynebacterium diphtheriae#N#-Treatment of erythrasma due to Corynebacterium minutissimum#N#-Treatment of listeriosis caused by Listeria monocytogenes#N#-Treatment of mild to moderate lower respiratory tract infections caused by Streptococcus pneumoniae (Diplococcus pneumoniae) or Streptococcus pyogenes (Group A beta-hemolytic streptococci [GAS])#N#-Treatment of mild to moderate skin and structure infections caused by Staphylococcus aureus or S pyogenes#N#-Treatment of mild to moderate upper respiratory tract infections caused by H influenzae (when used concomitantly with adequate doses of sulfonamides), S pneumoniae (D pneumoniae), or S pyogenes (GAS)#N#-Treatment of respiratory tract infections due to Mycoplasma pneumoniae#N#-Oral formulations: Treatment of intestinal amebiasis caused by Entamoeba histolytica.
ORAL:#N#Erythromycin Base (Base) or Erythromycin Stearate (Stearate):#N#Mild to moderate infections: 250 mg orally every 6 hours, 333 mg orally every 8 hours, OR 500 mg orally every 12 hours#N#Severe infections: 1 gram orally every 6 hours#N#-Maximum dose: 4 grams/day#N#Erythromycin Ethylsuccinate (Ethylsuccinate): 400 mg orally every 6 hours#N#-Maximum dose: Up to 4 grams/day#N#PARENTERAL:#N#Erythromycin Lactobionate (Lactobionate): 15 to 20 mg/kg IV per day via intermittent IV infusion over 20 to 60 minutes no more than every 6 hours or via slow continuous IV infusion#N#-Maximum dose: 4 grams/day#N#Duration of therapy:#N#-Intestinal amebiasis: 10 to 14 days#N#-Streptococcal infections: At least 10 days#N#Comments:#N#-This drug should be taken approximately 1 hour prior to meals.#N#-Higher doses may be increased (up to 4 grams/day), depending on the severity of the infection.#N#-Ethylsuccinate formulations doses may be given every 12 hours in 2 divided doses OR every 8 hours in 3 divided doses if desired.#N#-Many strains of Haemophilus influenzae are not susceptible to concentrations of this drug typically achieved by dosing; concomitant dosing with sulfonamides should be used in patients with upper respiratory tract infections caused by H influenzae.#N#-Resistant staphylococcal skin infections may reemerge with treatment.#N#-Patients with extrahepatic amebiasis should be given treatment with other antibiotics.#N#-Parenteral formulations should be replaced by oral formulations as soon as possible.#N#Uses:#N#-As an adjunct to antitoxin to prevent the establishment of carriers and to eradicate the organism in carriers of diphtheria caused by Corynebacterium diphtheriae#N#-Treatment of erythrasma due to Corynebacterium minutissimum#N#-Treatment of listeriosis caused by Listeria monocytogenes#N#-Treatment of mild to moderate lower respiratory tract infections caused by Streptococcus pneumoniae (Diplococcus pneumoniae) or Streptococcus pyogenes (Group A beta-hemolytic streptococci [GAS])#N#-Treatment of mild to moderate skin and structure infections caused by Staphylococcus aureus or S pyogenes#N#-Treatment of mild to moderate upper respiratory tract infections caused by H influenzae (when used concomitantly with adequate doses of sulfonamides), S pneumoniae (D pneumoniae), or S pyogenes (GAS)#N#-Treatment of respiratory tract infections due to Mycoplasma pneumoniae#N#-Oral formulations: Treatment of intestinal amebiasis caused by Entamoeba histolytica.
ORAL:#N#Erythromycin Base (Base) or Erythromycin Stearate (Stearate):#N#Mild to moderate infections: 250 mg orally every 6 hours, 333 mg orally every 8 hours, OR 500 mg orally every 12 hours#N#Severe infections: 1 gram orally every 6 hours#N#-Maximum dose: 4 grams/day#N#Erythromycin Ethylsuccinate (Ethylsuccinate): 400 mg orally every 6 hours#N#-Maximum dose: Up to 4 grams/day#N#PARENTERAL:#N#Erythromycin Lactobionate (Lactobionate): 15 to 20 mg/kg IV per day via intermittent IV infusion over 20 to 60 minutes no more than every 6 hours or via slow continuous IV infusion#N#-Maximum dose: 4 grams/day#N#Duration of therapy:#N#-Intestinal amebiasis: 10 to 14 days#N#-Streptococcal infections: At least 10 days#N#Comments:#N#-This drug should be taken approximately 1 hour prior to meals.#N#-Higher doses may be increased (up to 4 grams/day), depending on the severity of the infection.#N#-Ethylsuccinate formulations doses may be given every 12 hours in 2 divided doses OR every 8 hours in 3 divided doses if desired.#N#-Many strains of Haemophilus influenzae are not susceptible to concentrations of this drug typically achieved by dosing; concomitant dosing with sulfonamides should be used in patients with upper respiratory tract infections caused by H influenzae.#N#-Resistant staphylococcal skin infections may reemerge with treatment.#N#-Patients with extrahepatic amebiasis should be given treatment with other antibiotics.#N#-Parenteral formulations should be replaced by oral formulations as soon as possible.#N#Uses:#N#-As an adjunct to antitoxin to prevent the establishment of carriers and to eradicate the organism in carriers of diphtheria caused by Corynebacterium diphtheriae#N#-Treatment of erythrasma due to Corynebacterium minutissimum#N#-Treatment of listeriosis caused by Listeria monocytogenes#N#-Treatment of mild to moderate lower respiratory tract infections caused by Streptococcus pneumoniae (Diplococcus pneumoniae) or Streptococcus pyogenes (Group A beta-hemolytic streptococci [GAS])#N#-Treatment of mild to moderate skin and structure infections caused by Staphylococcus aureus or S pyogenes#N#-Treatment of mild to moderate upper respiratory tract infections caused by H influenzae (when used concomitantly with adequate doses of sulfonamides), S pneumoniae (D pneumoniae), or S pyogenes (GAS)#N#-Treatment of respiratory tract infections due to Mycoplasma pneumoniae#N#-Oral formulations: Treatment of intestinal amebiasis caused by Entamoeba histolytica.
As a result, the main goals of treatment for gastroparesis are alleviation of symptoms, correction of malnutrition, and resumption of adequate oral intake of liquids and solids.
Berkeley, California. US Pharm. 2019;44 (2):32-34. Gastroparesis is a chronic disorder that affects a significant subset of the population. Ordinarily, strong muscular contractions move food through the digestive tract. In gastroparesis, this mechanism is disrupted, and undigested food stays in the abdomen for a long time ...
Signs and symptoms of gastroparesis include a feeling of fullness after eating just a few bites, vomiting undigested food eaten a few hours earlier, acid reflux, abdominal bloating, abdominal pain, changes in blood sugar levels, lack of appetite, and weight loss. 3
Although there is no cure for gastroparesis, changes to the diet, along with medication, can offer some relief. 1,2. Certain medications, such as some antidepressants, opioid pain relievers, and high blood pressure and allergy medications, can lead to slow gastric emptying and cause similar symptoms.
Sometimes, treating the cause may stop the problem. If diabetes is causing gastroparesis, patients must control their blood glucose levels. Acute hyperglycemia may impair gastric motor function as well as inhibit the action of prokinetic drugs, such as erythromycin.
Erythromycin: This macrolide antibiotic has been available since the 1950s. It is rarely used as an antibiotic today and is primarily prescribed for its “prokinetic” effect on the gastrointestinal (GI) tract. It has been used successfully off-label for the treatment of gastroparesis and other GI hypomotility disorders.
It is especially essential for proper operation of the digestive tract. If the vagus nerve is damaged, transfer of food from the abdomen to the small intestine is reduced because the muscles will not operate properly. 4. Type 1 and type 2 diabetes are known to damage the vagus nerve.