If you've taken classes previously and you've done poorly, some schools will give you options. They might get rid of your old courses if you take a new set of classes. They might remove them from your transcript and expunge them.
Visit the registrar's office to find out if the school has a repeat/delete program. Universities that offer the repeat/delete program allow you to take the course you failed one more time. The registrar's office removes the first grade and replaces it with the new one, recalculating your grade-point average.
Many colleges do not remove courses from transcripts unless they have a compelling reason to do so. The rules for doing so vary by college, and your best bet is to contact the office of the registrar at your school. If you are unable to remove the course, you may be able to improve your grade and improve your average.
Set up an appointment with your university's registrar to seek to have a larger part of your academic record expunged, or if a professor refuses to or is unable to expunge it. Explain your personal situation to the registrar and ask her to expunge the record in light of your otherwise excellent academic performance.