The cell cycle is the process by which cells grow, replicate their genetic material, and divide. In eukaryotes, cell division is known as mitosis. The entire cell cycle is divided into four phases: G 1, S, G 2, and M. The G 1, S, and G 2 phases are collectively known as interphase.
The cell cycle is the continuum of cell growth and division in the life of a cell. Cell division in eukaryotes is called mitosis.
E1B-55k causes infected cells to transition out of the cell cycle and into G phase. E1B-55k increases the likelihood of cell cycle arrest in infected cells.
Regulation of cell cycle. Adenoviruses are a family of highly contagious viruses that most commonly cause illnesses of the respiratory system , such as bronchitis or pneumonia . In the first phase of an adenovirus infection, the host cell expresses several viral proteins.
One of these proteins, E1B-55k, inhibits the activity of the host protein p53, a tumor suppressor that arrests the cell cycle or induces apoptosis when DNA damage is detected.